Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsDiscover what a Phage Display library can do for your peptide research! We provide screening service using our ultra large capacity Phage Display TriCo-C9L Cyclic 9-mer Peptide Library. This superior cyclic 9-mer peptide library platform with intelligent trimer codon randomization to maintain high peptide diversity and target-binding specificity. With TriCo-C9L, there are already many successful cases for a wide range of targets. Benefit from our M13 phage display system for fast screening to jumpstart novel therapeutic or diagnostic research with us.
| Library ID | TriCo-C9L | Library Format | Cyclic 9-mer peptide library |
| Display Technology | M13 pIII fusion, phagemid phage display | Randomization | Trimer codon, avoid stop and non-sense codon |
| Vector System | pCDisplay-3M | Tags | His, Myc |
| Library Capacity | 6.8×1010 | Host Strain | E. coli TG1 |
The cyclic 9-mer peptides not only provide better stability against enzymatic cleavage, but also pre-organized conformation. The rigid cyclic form also usually displays much higher affinity and specificity compared to their linear counterpart, because peptides have “paid” the entropic cost of binding through its constrained structure. This leads to a highly optimized conformation for interaction with the target, with reduced risk of off-target binding. Our stringent QC ensures >97% function confirmed inserts, to provide a high-quality starting library.
Our tri-co codon (TriCo) randomization strategy allows for the highest functional diversity in the library. With a peptide universe of >1010 distinct cyclic variants, the ultra-large capacity library significantly increases the probability of identifying novel functional binders for your needs. This is especially useful for screening against high-difficulty targets, and support numerous therapeutic, diagnostic and research applications.
We employ our gold-standard true phage display system to help identify high-affinity peptides. This proven and reliable technology offers exceptional sensitivity for discovering therapeutic peptides across diverse and challenging targets, ensuring trustworthy and reproducible results.
Paired with our high-throughput screening platform, the TriCo-C9L enables rapid, large-scale identification of promising cyclic candidates. Our customizable screening capabilities are tailored to your specific research needs, allowing precise optimization for various biological interactions and fast-tracking projects towards preclinical development.
The cyclic design yields candidates with high specificity and strong affinity, crucial for developing compounds with minimal off-target interactions. Importantly, the cyclic structure significantly improves the peptide's metabolic stability and in vivo half-life, vital for developing effective therapeutics with enhanced bioavailability.
Choose our TriCo-C9L library for a one-stop service in peptide binder screening and development, particularly for high-difficulty targets. This powerful tool ensures precision, speed, and a higher likelihood of success for your novel therapeutic, diagnostic, and epitope mapping projects, transforming your research into impactful applications.
Our Phage Display TriCo-C9L Peptide Library allows us to offer a diverse menu of custom peptide discovery services, which are designed for specific research needs in a wide range of applications. Using the power of phage display technology, we can identify high-affinity peptide binders for your peptide research of many different types of targets from antigen epitopes to small molecules and even non-biological targets such as polymers and particulates.
Here is a list of the peptide discovery services customized for your research needs:
Epitope Specific Peptide Discovery
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Cell-Targeted Peptide Discovery |
Disease-Specific Peptide Discovery
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Particulate Matter Binding Peptide Screening
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Soft Matter Binding Peptide Screening
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To simplify the screening process, we offer a comprehensive, seamless workflow designed to save you time and effort while delivering high-quality peptide candidates tailored for your research or therapeutic needs.
Provide us with your antigen details (recombinant protein, peptide, small molecule, cells, etc.) for initial screening.
We perform multi-round biopanning using the TriCo-C9L library under optimized conditions to ensure high-affinity binders are selected.
After screening, we deliver a detailed report including peptide sequences, binding data (e.g., ELISA or SPR), and clone information.
Our expert scientific team provides ongoing guidance to help you validate and optimize the peptide candidates for your specific application, be it therapeutic or diagnostic.
| Cell Internalizing Peptide Discovery via TriCo-C9L Peptide Library | ||
Targeted Peptide Selection 
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Objective | Identify peptides capable of internalizing into specific cell types. |
| Method | Utilized customer-provided cell types as the primary targets, with related cell types as negative controls. | |
| Process | Conducted four rounds of phage display selection, resulting in significant enrichment of peptides with high affinity for the target cells. | |
NGS Validation of Enriched Library 
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Objective | Verify the enrichment and identify top peptide sequences. |
| Method | Performed Next-Generation Sequencing (NGS) to analyze the enriched library. | |
| Results | The top 3 peptide sequences showed high abundance, confirming specific enrichment of relevant peptides for internalization. | |
| Customer Validation & Downstream Development | Objective | Confirm peptide functionality and enable further development. |
| Method | Peptides were internally validated by the customer through in vitro assays. | |
| Outcome | Positive validation led to downstream applications in further research and development, including therapeutic targeting and diagnostic testing. | |
Beyond our cutting-edge TriCo-C9L Cyclic 9-mer Peptide Library, we offer a diverse array of premade peptide libraries to suit various research needs, including linear 16-mer and 20-mer libraries. To further support your peptide development efforts, we provide flexible options such as library licensing for in-house use, as well as comprehensive custom peptide screening and identification services. This ensures you have access to the ideal tools and expertise to advance your projects from discovery to validation.
| Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| TriCo-16 | pIII-fusion, True Phage Display | 16-mer peptide library | 1.1×1010 | ✔️ |
| TriCo-20 | pIII-fusion, True Phage Display | 20-mer peptide library | 1.3×1010 | ✔️ |
| TriCo-C9 | pIII-fusion, Phagemid Phage Display | Cyclic 9-mer peptide library | 1.1×1010 | ✔️ |
| TriCo-C9L | pIII-fusion, Phagemid Phage Display | Cyclic 9-mer peptide library | 6.8×1010 | Screening-only |
| Protease-10A | pIII-fusion, Phagemid Phage Display | HiAffi tagged 10 mer peptide library | 1.1×1010 | ✔️ |
Contact us for more information on how our libraries and screening platforms can help you achieve your research goals!
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
