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HighlightsBasigin (BSG), also known as extracellular matrix metalloproteinase inducer (of EMMPRIN) or cluster of differentiation 147 (CD147), is a human protein encoded by the BSG gene. This protein is a determining factor in the Ok blood group system. BSG has been shown to be an essential receptor for the red blood cells of the human malaria parasite Plasmodium falciparum.
| Basic Information of BSG | |
| Protein Name | Basigin |
| Gene Name | BSG |
| Aliases | 5F7, EMMPRIN, TCSF, CD147 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P35613 |
| Transmembrane Times | 3 |
| Length (aa) | 385 |
| Sequence | MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS |
BSG is a member of the immunoglobulin superfamily and has structures associated with the putative original form of the family. As a member of the immunoglobulin superfamily involved in a variety of immune phenomena, it is considered that BSG also plays a role in cell recognition. In addition to its ability to induce metalloproteinase, BSG also regulates several different functions, e.g. spermatogenesis, and the expression of lymphocyte reaction monocarboxylic acid transporter. BSG has a number of type I integral membrane receptor ligands, comprising cyclophilin protein Cyp-A and CyP-B, as well as certain integrins.
Fig.1 Structure of BSG membrane protein.
This article reports that BSG belongs to the immunoglobulin superfamily and may be related to the primordial form of the superfamily.
This article reveals the specific and limited expression of 5A11/Basigin-2 explicitly within photoreceptor cells implies that this glycoprotein plays a fundamental role within the retina.
This article suggests that BSG in tumor cells triggers the production or release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, thereby contributing to tumor invasion.
This article suggests the involvement of a cyclophilin in the regulation of intracellular transport of CD147.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-BSG antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
