shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(C3orf37-shRNA-Seq1)(CAT#: AdV-SI0405WQ)
This product is a C3orf37-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The C3orf37 gene acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The expression of C3orf37-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | C3orf37-shRNA-Seq1 |
Related Target/Protein | C3orf37 |
Region | CDS |
TargetSeq | CTACCAACTGTCGTAGTGATA |
NCBI RefSeq | NM_020187 |
Alternative Names | DC12; SRAPD1; HMCES |
Titer | >1*10^10 GC/mL |
Related Diseases | DNA demethylation |