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HighlightsNeuroplastin, encoded by the NPTN gene, is a cell adhesion molecule of the immunoglobulin superfamily. The proteins of this family usually contain several extracellular immunoglobulin domains derived from alternative splicing from a single gene, and a single transmembrane and a short intracellular domain. NPTN is enriched in the brain (neuronal and synapse). NPTN may be involved in cell-cell interactions or cell-substrate interactions.
| Basic Information of NPTN | |
| Protein Name | Neuroplastin |
| Gene Name | NPTN |
| Aliases | Stromal cell-derived receptor 1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9Y639 |
| TransmNPTNrane Times | 1 |
| Length (aa) | 398 |
| Sequence | MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN |
The best-known function of NPTN is to act as a possible heterophilic and homophilic cell adhesion molecule to play a role in long-term potentiation at hippocampal excitatory synapses through activation of the p38-MAPK pathway. It can also regulate the outgrowth of neurite by activating the pathway of FGFR1 signaling to play important roles in synaptic maturation and plasticity. In addition, NPTN is shown to be involved in hippocampal synaptic plasticity by regulating the number and function of synapses in the hippocampus. Meanwhile, NPTN may be involved in genetic susceptibility to schizophrenia.
Fig.1 Predicted structure of NPTN in the repository of SWISS-MODEL. (Bienert, 2017)
This review generalizes the roles of Neuroplastins for correct localization of synaptic membrane protein, expression of LTP and LTD, neuronal energy supply, pathophysiology, and disease, as well as animal and human behavior. Its content focuses mainly on signaling mechanisms and Neuroplastin binding partners and proposes viewpoints for further research.
This article reports the changes of neuroplastin expression in the B4galnt1 null mice hippocampus, which do not have the complex ganglioside structures in comparison with wild-type mice. However, the expression of neuroplastin mRNA is significantly higher in the hippocampi of B4galnt1 null mice than in wild-type mice.
This article demonstrates that neuroplastin is indispensable for amplification of sound and that polymorphism in neuroplastin leads to impairment of auditory in mice.
This article strongly suggests that neuroplastins function as crucial auxiliary proteins for MCT2 localization in cell surface and activity in some neuronal populations, thus having a significant role in promoting the lactate uptake for use as a respiratory fuel.
This article reviews the neuroplastin structure and mechanisms involved in neuroplastin signaling and discusses the functions of neuroplastins in the nervous system.
In order to provide high-quality membrane protein preparation service, we have developed a versatile Magic™ membrane protein production platform. Our experienced scientists will do their best to help you find a perfect match in your required formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-NPTN antibody development services.
Creative Biolabs is dedicated to providing first-class membrane protein production service using a variety of strategies. Based on our leading-edge platform, we have successfully produced, purified, stabilized and characterized many challenging membrane protein targets for global customers. If you are interested in the service we can provide, please feel free to contact us for more information.
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