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POPDC2 Membrane Protein Introduction

Introduction of POPDC2

Popeye domain-containing protein 2, also known as Popeye protein 2, is a protein encoded by the POPDC2 gene in humans. This gene encodes the POP family member of proteins that contains three putative transmembrane domains. This membrane-associated protein is mainly expressed in bone and myocardium. The Popeye domain located in the cytoplasmic portion of the protein shows limited sequence homology with other proteins, while in the Popeye protein, the sequence protection rate is high, about 40%-60%.

Basic Information of POPDC2
Protein Name Popeye domain-containing protein 2
Gene Name POPDC2
Aliases Popeye protein 2
Organism Homo sapiens (Human)
UniProt ID Q9HBU9
Transmembrane Times 2
Length (aa) 364
Sequence MSANSSRVGQLLLQGSACIRWKQDVEGAVYHLANCLLLLGFMGGSGVYGCFYLFGFLSAGYLCCVLWGWFSACGLDIVLWSFLLAVVCLLQLAHLVYRLREDTLPEEFDLLYKTLCLPLQVPLQTYKEIVHCCEEQVLTLATEQTYAVEGETPINRLSLLLSGRVRVSQDGQFLHYIFPYQFMDSPEWESLQPSEEGVFQVTLTAETSCSYISWPRKSLHLLLTKERYISCLFSALLGYDISEKLYTLNDKLFAKFGLRFDIRLPSLYHVLGPTAADAGPESEKGDEEVCEPAVSPPQATPTSLQQTPPCSTPPATTNFPAPPTRARLSRPDSGILASRIPLQSYSQVISRGQAPLAPTHTPEL

Function of POPDC2 Membrane Protein

Bacterial CAP or CRP proteins, the closest related non-POPDC proteins, act as a circulating nucleotide regulatory transcription factor that regulates the expression of genes that encode enzymes involved in carbohydrate metabolism. The cyclic AMP binding domain of these proteins and the energetic watergate domain showed approximately 25% identity and 60% similarity. There are significant structural similarities between the Popeye domain and the cAMP binding domain of eukaryotic protein kinase A (PKA) and the HCN channel. The genetic inactivation of Popdc2 in mice resulted in mild and chronic arrhythmias, which were heavily dependent on stress. Normal ECG was observed at rest. Gene inactivation in zebrafish also leads to arrhythmia phenotypes and skeletal muscle development defects. Popdc2 is expressed in skeletal muscle and heart. The global loss of popdc2 affects skeletal muscle development, leading to abnormal facial and trunk muscle formation.

POPDC2 Membrane Protein IntroductionFig.1 The structure of Popeye domain-containing protein 2.

Application of POPDC2 Membrane Protein in Literature

  1. Dupays L., et al. Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell Reports. 2015, 13 (1): 183-195. PubMed ID: 26411676

    This study reveals that binding these two factors to these overlapping sites is mutually exclusive, which provides a simple tuning mechanism for spatial and temporal synchronization of the common target pool between nkx2-5 and MEIS1.

  2. Schindler R.F.R., et al. The Popeye Domain Containing Genes and Their Function in Striated Muscle. Journal of Cardiovascular Development and Disease. 2016, 3 (2): 22. PubMed ID: 27347491

    These results show that this family of cAMP-binding proteins may play multiple roles in striated muscle.

  3. Kirchmaier B.C., et al. The Popeye Domain Containing 2 (popdc2) Gene in Zebrafish Is Required for Heart and Skeletal Muscle Development. Developmental biology. 2012, 363 (2): 438-450. PubMed ID: 22290329

    These results suggest that popdc2 is an important gene that is critical for muscle differentiation and cardiac morphogenesis. It is also necessary for the development of the heart conduction system.

  4. Schindler R. F., et al. The Popeye Domain Containing Genes: Essential Elements in Heart Rate Control. Cardiovascular Diagnosis and Therapy. 2012, 2 (4): 308-319. PubMed ID: 24282731

    This study reveals that the molecular basis of stress bradycardia in Popdc mice will provide new clues to the etiology of cardiac pacemaker disease.

  5. Brand T., et al. The cAMP-Binding Popdc Proteins Have a Redundant Function in the Heart. Biochemical Society Transactions. 2014, 42. (Pt 2): 295-301. PubMed ID: 24646234

    This research identifies a family of membrane-bound cAMP-binding proteins, which regulate the subcellular localization of effector proteins, participate in tissue signaling complexes and ensure proper membrane physiology of cardiomyocytes.

POPDC2 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Besides, aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-POPDC2 antibody development services.


Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

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