Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSyntaxins are the prototype family of SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein)-attachment protein receptor] proteins involved in the membrane fusion process of synaptic vesicles with the presynaptic plasma membrane. In the exocytic and the endocytic pathway, syntaxins can mediate vesicle fusion in diverse vesicular transport processes through binding to other SNAREs and with the cytoplasmic NSF and SNAP. Besides, syntaxins can bind synaptotagmin in a calcium-dependent fashion and interact with voltage-dependent calcium and potassium channels involved in the depolarization of the presynaptic axonal boutons. Syntaxins have a similar structure that contains a single C-terminal pass-membrane domain, a SNARE domain, and an N-terminal domain. The SNARE domain can bind to both synaptobrevin and SNAP-25 forming the core SNARE complex which provides the free energy for initiating the fusion of vesicle membrane and plasma membrane. The N-terminal domain is a regulator of syntaxin conformation.
There are 15 members of the syntaxin family in the human genome. Here shows part of syntaxins in humans including STX1A, STX7, and STX8. STX1A plays an essential role in the regulation of ion channel and synaptic exocytosis. STX8 can form the SNARE complex with syntaxin 7, vti1b and endobrevin participating in the homotypic fusion of late endosomes.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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