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Bestrophin Protein Family

The bestrophin family of proteins comprises four protein members containing bestrophin-1, bestrophin-2, bestrophin-3, and bestrophin-4, that are respectively encoded by evolutionarily related genes BEST1, BEST2, BEST3, and BEST4. Bestrophin, present in retinal pigment epithelial cells (RPE), is a basolateral plasma membrane protein with a molecular weight of 68 kDa. The proteins from this small family consisting of a highly conserved N-terminus with four to six transmembrane domains. Related research has shown that bestrophins are capable of forming calcium-activated chloride-ion channels in epithelial cells, however, they have been demonstrated highly permeable to bicarbonate ion transport in retinal tissue. In addition, bestrophins may play a role in the formation of chloride ion channels or the regulation of voltage-gated L-type calcium-ion channels.

Here, we present part of bestrophin transport proteins in humans including the following two different family members including bestrophin-1 and bestrophin-2.

Human Bestrophin Protein Family Members
BEST1 BEST2

Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line with the support of cutting-edge Magic™ membrane protein production platform.

Magic™ membrane protein production platform – Creative Biolabs

In addition, our Magic™ membrane protein antibody discovery platform provides a good choice to assist our worldwide clients to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

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