| Protein Name | C-C chemokine receptor type 4 |
| Gene Name | CCR4 |
| Uniprot | P51679 (Human); P51680 (Mouse) |
| Synonym | CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; C-C CKR-4; CCR-4 |
| Background | CCR-4 (designated CD194), which belongs to the G-protein-coupled receptor family, is encoded by the CCR4 gene. It is a receptor for the CC chemokine including CCL2 (MCP-1), CCL4 (MIP-1), CCL5 (RANTES), CCL17 (TARC), and CCL22 (Macrophage-derived chemokine). CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). And it was indicated to be predominantly expressed by medullary CD4-single positive thymocytes expressing CD30, supporting its possible role in negative selection. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX479 | NativeExtract™ Human CCR4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX55 | MemDX™ Recombinant Human CCR4 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX0909K | MemDX™ Membrane Protein Human CCR4 (C-C motif chemokine receptor 4) Expressed in vitro E.coli expression system, Full Length | E.colicell-free | Full length | Detergent |
| S01YF-0423-KX14 | MemDX™ Human CCR4 Membrane Protein in Membrane Nanoparticles (MNP), Full Length | HEK293 cells | Full length | N/A |
| S01YF-0423-KX483 | MemDX™ Membrane Protein Human CCR4 (1-39aa) Expressed in HEK293, C-Human Fc | HEK293 cells | Partial | N/A |
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H***y: I recently purchased the CCR4 protein from Creative Biolabs, and I must say, I am thoroughly impressed! The protein arrived on time and was in perfect condition. The team at Creative Biolabs is highly professional and responsive. They provided detailed documentation and support throughout the process.
21/ Aug/2023
S***er: I have been using proteins from Creative Biolabs for a while now. It is of excellent purity and has shown consistent results in my assays. The customer service is outstanding; they are always available to answer questions and provide guidance.
23/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers genome editing services. Genome editing technologies can be used to specifically knock out the CCR4 gene in cancer cells. This method has shown potential in personalized cancer therapy.
Creative Biolabs offers aptamer-based therapies research services. Aptamers are short, single-stranded oligonucleotides that can bind specifically to biological molecules. Aptamers targeting CCR4 can be incorporated into delivery systems to selectively target CCR4-expressing cells.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR4 cell therapy. Please for more services.
Creative Biolabs offers CAR-T cell therapy development and preclinical research services. CAR-T therapy targeting CCR4 is an emerging approach in cell therapy. CCR4-specific CAR-T cells can effectively lyse primary CTCL cells and produce significant antitumor activity.
Creative Biolabs offers expert support for membrane protein studies with best-in-class membrane protein preparation strategies and procedures. Performance and delivery are further enhanced by our design and implementation of state-of-the-art technologies. Please feel free to for expert advice.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.