Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-C chemokine receptor type 5 |
| Gene Name | CCR5 |
| Uniprot | P51681 (Human); P51682 (Mouse) |
| Synonym | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; HIV-1 fusion coreceptor |
| Background | CCR-5 (designated as CD195), is a membrane receptor protein encoded by CCR5 gene which is found in human immune cells such as monocytes and lymphocytes. CCR-5 is highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. CCR-5 is a receptor for several inflammatory CC chemokines including MIP-1-alpha, MIP-1-beta, and RANTES. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX394 | NativeExtract™ Human CCR5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPVLP-007 | MemDX™ Recombinant Human CCR5 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPVLP-008 | MemDX™ Recombinant Mouse CCR5 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MP1334J | MemDX™ Membrane Protein Human CCR5 (C-C motif chemokine receptor 5) for Antibody Discovery | E.colicell-free | Full length | Detergent |
| MP0170X | MemDX™ Membrane Protein Human CCR5 (C-C motif chemokine receptor 5) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
R***y: MemDX™ Recombinant Human CCR5 Membrane Protein in Virus-Like Particles (MP-VLPs)
The ELISA activity of the protein is outstanding. It performed exceptionally well in my experiments, providing clear and reliable results. The high purity and functionality of the protein make it an excellent choice for researchers working on CCR5-related projects.
11/ Nov/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers genome editing services. Genome editing has emerged as a powerful tool for gene editing, particularly for targeting the CCR5 gene. Studies have shown that CRISPR/Cas9-mediated knockout of CCR5 in human hematopoietic stem cells (HSCs) can confer resistance to HIV-1 infection.
Creative Biolabs offers optimized gRNA selection services. Recent research has identified optimal gRNAs that induce robust ablation of CCR5 expression on human T cells. Some gRNAs have been shown to induce efficient CCR5 gene editing, with editing efficiencies ranging from 52% to 70%.
Creative Biolabs offers off-target detection services. Minimizing off-target effects is crucial for the safety and efficacy of CCR5 gene therapy. Recent studies have employed advanced techniques such as amplicon sequencing and droplet-digital PCR (ddPCR) to identify and quantify off-target modifications.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR5 cell therapy. Please for more services.
Creative Biolabs offers development and preclinical research services in combination therapies. Combining CRISPR/Cas9-mediated CCR5 knockout with other antiviral strategies has shown potential for enhanced efficacy. This combination approach leverages the strengths of both gene editing and antiviral fusion inhibitors to maximize therapeutic outcomes.
Creative Biolabs has worked all out in the field of membrane protein preparation to support membrane protein studies. We are recognized as the world leader in providing the largest and most diverse portfolio of standard and custom professional membrane protein preparation services. Please feel free to for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
