CCR-L2 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of CCRL2

Protein Name	C-C chemokine receptor-like 2
Gene Name	CCRL2
Uniprot	O00421 (Human); O35457 (Mouse)
Synonym	HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B; C-C chemokine receptor-like 2; atypical chemokine receptor 5; chemokine (C-C motif) receptor-like 2; chemokine receptor CCR11; chemokine receptor X; putative MCP-1 chemokine receptor
Background	CCR-L2, alternatively known as chemokine receptor CCR11 or putative MCP-1 chemokine receptor, is in human encoded by CCRL2 gene. It is supposed to be a non-signaling seven transmembrane (7-TMD) protein and is related to the atypical chemokine receptor (ACKR) family. The ligands of CCR-L2 have been identified to be CCL19 and chemerin/RARRES2. CCR-L2 is highly expressed in primary neutrophils and primary monocytes and is further increased during monocyte to macrophage differentiation and neutrophil activation.

CCRL2 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX293	NativeExtract™ Human CCRL2 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MP1339J	MemDX™ Membrane Protein Human CCRL2 (C-C motif chemokine receptor like 2) for Antibody Discovery	E.colicell-free	Full length	Detergent
MP0177X	MemDX™ Membrane Protein Human CCRL2 (C-C motif chemokine receptor like 2) with GST-tag for Antibody Discovery	Wheat germ cell-free	Full length	N/A
MP0176X	MemDX™ Membrane Protein Human CCRL2 (C-C motif chemokine receptor like 2) without tag for Antibody Discovery	Wheat germ cell-free	Full length	Liposome
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Customer Reviews

H***er: I recently purchased the CCRL2 protein from Creative Biolabs, and I am extremely satisfied with my purchase. The protein arrived promptly and was in excellent condition. The quality and purity of the protein are outstanding, which is crucial for the accuracy of my research.

10/ Jun/2023

Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

CCRL2 Drug Discovery and Development

CCRL2 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-CCRL2 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

CCRL2 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Viral Vector-Based Approaches

Creative Biolabs offers viral vector-based delivery services. AAV vectors are commonly used in gene therapy due to their low immunogenicity and ability to infect a wide range of cell types. They can be engineered to deliver CCRL2-specific shRNA or siRNA to knock down CCRL2 expression, or to deliver a corrected CCRL2 gene in cases of genetic mutations. Lentiviral vectors are another option for delivering CCRL2-related genetic modifications. They can integrate into the host genome and provide long-term expression of the introduced gene. This makes them suitable for applications such as the stable expression of CCRL2 in immune cells.

RNA Interference (RNAi)

Creative Biolabs offers RNAi services. Design and synthesize siRNA molecules that specifically target CCRL2 mRNA. These siRNAs can be delivered into cells using liposomes or other delivery systems to reduce CCRL2 expression. This method is useful for studying the effects of CCRL2 knockdown on cell behavior and disease progression. shRNA can be expressed from a viral vector or a plasmid to continuously degrade CCRL2 mRNA in target cells. This approach can be used to create stable cell lines with reduced CCRL2 expression for long-term studies.

CCRL2 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of CCRL2 cell therapy. Please inquire with us for more services.

In Vitro Functional Assays

Creative Biolabs offers in vitro functional assays services. Perform chemotaxis assays to assess the migratory response of CCRL2-expressing cells to relevant chemokines. This can provide insights into the role of CCRL2 in guiding cell movement, particularly in immune cell trafficking and tissue homing. Evaluate the proliferative capacity and activation status of CCRL2-positive cells using cell proliferation assays and intracellular cytokine staining. This helps in understanding how CCRL2 signaling impacts cell division and effector functions.

Co-Culture Systems

Creative Biolabs offers co-culture systems development services. To elucidate the functional consequences of CCRL2 expression in modulating cellular dialogues, in vitro co-culture systems represent a pertinent experimental approach. Specifically, co-culturing CCRL2-positive cells directly with tumor cells, or alternatively with key stromal cell components characteristic of the tumor microenvironment (TME), can provide significant insights. This parallel experimental strategy is designed explicitly to probe the functional involvement of CCRL2 in processes potentially governing tumor progression and its interplay within the complex TME milieu.

Creative Biolabs works all out to provide a comprehensive solution for membrane protein studies for our worldwide clients. We conduct not only regular membrane protein preparation service, but also customize it based the requirements of the clients to meet the specific demand. Please feel free to contact us for expert support.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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