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Dipeptidyl Peptidase Family

Dipeptidyl peptidase (DPP) family has been implicated in various physiological processes and pathologies of the immune system. This family consists of several prolyl-specific peptidases, including DPPIV, fibroblast activation protein α (FAP), prolyl oligopeptidase (PREP), dipeptidyl peptidase II (DPPII), and prolyl carboxypeptidase, and etc. DPPIV is one of the prototypical DPP, cleaves off an N-terminal dipeptide from peptides with Pro or Ala on the penultimate position. The protein fold of the peptidase domain for DPP family members is similar to that of serine carboxypeptidase D, the type example of clan SC. DPPs are found in epithelial cells of a large number of organs, such as gut, liver, and kidney; in endothelial capillaries; in the uterus; in acinar cells of mucous and salivary glands and pancreas; and by immune organs including thymus, spleen and lymph node.

Previous studies have indicated that the dipeptidyl peptidase family is involved in various physiological processes and pathologies of the immune system. And they have been considered as the potential marker for a number of cancers, but with variability among different types of cancers. Here shows part of dipeptidyl peptidase family members in human for your review.

Human Dipeptidyl Peptidase Members Family Members
DPP10 DPP6

Based on our efficient Magic™ membrane protein production platform, Creative Biolabs is ready to provide the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Moreover, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. In addition, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

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