Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Purinergic receptor P2Y2 |
| Gene Name | P2RY2 |
| Uniprot | P41231 (Human); P35383 (Mouse) |
| Synonym | P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R; P2Y purinoceptor 2; ATP receptor; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; purinergic receptor P2Y, G-protein coupled, 2; purinoceptor P2Y2 |
| Background | P2RY2 is encoded by the P2RY2 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is an important drug target and approximately 34% of all FDA approved drugs targeting this family. It is one of the eight subtypes of P2Y receptors (P2RY1, P2RY2, P2RY4, P2RY6, P2RY11, P2RY12, P2RY13 and P2RY14). P2RY2 possesses seven transmembrane alpha helices and is activated by extracellular nucleotides. Meanwhile, P2RY2 is also known as ATP receptor, P2U purinoceptor 1, P2U receptor 1 and purinergic receptor. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX82 | NativeExtract™ Human P2RY2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3499K | MemDX™ Membrane Protein Human P2RY2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0995X | MemDX™ Membrane Protein Human P2RY2 (Purinergic receptor P2Y2) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
Da***ell: Creative Biolabs' P2RY2 demonstrates exceptional batch consistency with preserved native conformation.
24/Jan/2023
Ev***er: Their gene-to-vial service delivered tailored C-terminal tags within 4 weeks, coupled with detailed biophysical characterization data exceeding industry standards.
06/Jul/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Editing for P2RY2 Transcriptional Modulation
Creative Biolabs offers gene editing services for P2RY2 transcriptional modulation. The integration of gene-editing systems enables precise genomic editing of the P2RY2 locus to modulate receptor expression in pathological states. For instance, allele-specific guide RNAs can be designed to target regulatory regions upstream of P2RY2, facilitating transcriptional activation in hypofunctional genetic backgrounds associated with impaired mucociliary clearance in chronic respiratory diseases. Creative Biolabs' proprietary genome-editing validation platforms provide robust screening for on-target efficiency and off-target minimization, ensuring therapeutic specificity.
Recombinant AAV Vector-Mediated P2RY2 Gene Delivery
Creative Biolabs offers recombinant AAV vector-mediated P2RY2 gene delivery services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters permit localized P2RY2 transgene delivery to epithelial compartments. Preclinical studies demonstrate that AAV9 serotypes, when coupled with airway epithelial-targeting capsids, restore P2RY2-dependent calcium signaling in cystic fibrosis models, enhancing chloride ion transport and mucin hydration. Such advancements highlight the potential for Creative Biolabs' viral vector development services to accelerate translational pipelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of P2RY2 cell therapy. Please for more services.
Engineered CAR-T Cells Targeting P2RY2-Overexpressing Malignancies
Creative Biolabs offers engineered CAR-T cells development services targeting P2RY2-overexpressing malignancies. Chimeric antigen receptor (CAR)-T cells redirected against P2RY2-overexpressing tumor microenvironments exploit receptor-ligand interactions for localized cytotoxicity. In hematological malignancies, P2RY2 serves as a biomarker of chemoresistant clones; CAR-T constructs incorporating P2RY2-binding domains exhibit enhanced tumor penetration and persistence in preclinical trials. Creative Biolabs' immunofluorescence imaging platforms enable high-resolution tracking of CAR-T spatial distribution within complex tissue architectures.
Stem Cell-Derived P2RY2 Agonist Secretion Systems
Creative Biolabs offers stem cell-derived P2RY2 agonist secretion systems development services. Induced pluripotent stem cells (iPSCs) genetically modified to secrete P2RY2-targeted agonists, such as nucleotide analogs, offer paracrine modulation of fibrotic pathways. In cardiac regeneration models, these cells reduce collagen deposition by suppressing TGF-β1-driven fibroblast activation via P2RY2 agonism. Our cell-specific viral vector development services ensure precise transcriptional control of therapeutic transgenes during iPSC differentiation.
P2RY2's dual role in ion homeostasis and immune modulation necessitates tailored therapeutic strategies. Creative Biolabs' integrated platforms, spanning genotyping, gene expression profiling, and cell-specific delivery systems, empower researchers to deconvolute receptor pleiotropy and prioritize clinical candidates. to optimize your P2RY2 drug development pipeline through customized genomic and cellular engineering solutions.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
