Potassium (K+) channels represent a broad and structurally heterogeneous class of voltage- and ligand-gated ion channels contributing to complex physiology processes, such as regulation of neurotransmitter release or neuronal excitability control. Potassium channel subfamily T, also known as the SLO2 family of Na+-dependent (K+) channel, belongs to the big family of potassium (K+) channels. To date, two members of the potassium channel subfamily T have been identified which denoted KCNT1 (Slo2.2 or Slack) and KCNT2 (Slo2.1 or Slick). They are structurally highly related and can form homo- or heteromeric channels. Studies have shown that KCNT1 and KCNT2 are widely distributed in the rat brain with partial overlap in their expression patterns. What’s more, KCNT1 could encode a sodium-gated potassium channel subunit that plays an important role in regulating excitability in neurons. And it is associated with a spectrum of focal epilepsy disorders. Whereas KCNT2 has been suspected of being a promising candidate gene for epilepsy.
Here, we have described in detail of members of the KCNT protein family, including potassium channel subfamily T member 1 and potassium channel subfamily T member 2. To learn more detailed information, please click the links below.
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