Close

Potassium Channel Subfamily T

Potassium (K+) channels represent a broad and structurally heterogeneous class of voltage- and ligand-gated ion channels contributing to complex physiology processes, such as regulation of neurotransmitter release or neuronal excitability control. Potassium channel subfamily T, also known as the SLO2 family of Na+-dependent (K+) channel, belongs to the big family of potassium (K+) channels. To date, two members of the potassium channel subfamily T have been identified which denoted KCNT1 (Slo2.2 or Slack) and KCNT2 (Slo2.1 or Slick). They are structurally highly related and can form homo- or heteromeric channels. Studies have shown that KCNT1 and KCNT2 are widely distributed in the rat brain with partial overlap in their expression patterns. What’s more, KCNT1 could encode a sodium-gated potassium channel subunit that plays an important role in regulating excitability in neurons. And it is associated with a spectrum of focal epilepsy disorders. Whereas KCNT2 has been suspected of being a promising candidate gene for epilepsy.

Here, we have described in detail of members of the KCNT protein family, including potassium channel subfamily T member 1 and potassium channel subfamily T member 2. To learn more detailed information, please click the links below.

Human KCNT Protein Family Members
KCNT1 KCNT2

Based on our cutting-edge Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us