Close

Sodium/Potassium Transporting ATPase Family

Sodium/potassium transporting ATPase (Na+/K+ ATPase), also known as sodium-potassium pump (Na+/K+ pump), is a plasma membrane transport protein found in many cells. Na+/K+ ATPase is a heterodimeric protein that consists of a catalytic α-subunit and a regulatory β-subunit. It transports three sodium ions out and two potassium into the cell across the membrane depending on the energy released from per ATP decomposition. Na+/K+ ATPase is very important for regulating fluid volume, and transmission of nerve impulses through mediating resting membrane potential and action membrane potential in the nervous system. It also functions as a signal transducer to regulate MAPK pathway, ROS, as well as intracellular calcium. The dysfunction of Na+/K+ ATPase can lead to abnormal biological conditions. For example, blockage of Na+/K+ ATPase in the cerebellum of a live mouse can lead to ataxia and dystonia.

Here are part of Na+/K+ ATPase including ATP1B1, ATP1B2, and ATP1B3. ATP1B1, encoded by ATP1B1 gene, is involved in cell adhesion and establishing epithelial cell polarity. ATP1B2, encoded by ATP1B2 gene, regulates cell adhesion of neurons and astrocytes as well as promotes neurite outgrowth. However, the exact function of the ATP1B3 is not clear.

Human Na+/K+ ATPase Family Members
ATP1B1 ATP1B2 ATP1B3

Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us