Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSodium/potassium transporting ATPase (Na+/K+ ATPase), also known as sodium-potassium pump (Na+/K+ pump), is a plasma membrane transport protein found in many cells. Na+/K+ ATPase is a heterodimeric protein that consists of a catalytic α-subunit and a regulatory β-subunit. It transports three sodium ions out and two potassium into the cell across the membrane depending on the energy released from per ATP decomposition. Na+/K+ ATPase is very important for regulating fluid volume, and transmission of nerve impulses through mediating resting membrane potential and action membrane potential in the nervous system. It also functions as a signal transducer to regulate MAPK pathway, ROS, as well as intracellular calcium. The dysfunction of Na+/K+ ATPase can lead to abnormal biological conditions. For example, blockage of Na+/K+ ATPase in the cerebellum of a live mouse can lead to ataxia and dystonia.
Here are part of Na+/K+ ATPase including ATP1B1, ATP1B2, and ATP1B3. ATP1B1, encoded by ATP1B1 gene, is involved in cell adhesion and establishing epithelial cell polarity. ATP1B2, encoded by ATP1B2 gene, regulates cell adhesion of neurons and astrocytes as well as promotes neurite outgrowth. However, the exact function of the ATP1B3 is not clear.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
