Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute Carrier Family 19 (SLC19), also known as the folate/thiamine transporter family, is a family of three transporter proteins with significant structural similarities, transporting, but have a different structure and ionic charge. The three members of the SLC19 family are commonly expressed and mediate the transport of two important water-soluble vitamins, folate and thiamine. SLC19A1 transports folate and its derivatives that exist as anions at physiological pH, while SLC19A2 and SLC19A3 transport thiamine, which exists as a cation at physiological pH. However, one functional feature is common among these three types of transporters. All of these are energized by a transmembrane pH gradient but with different mechanisms. Folate transporter also mediates the transport of methotrexate, an antineoplastic and immunosuppressive agent. Since folate and thiamine play important roles in cellular metabolism, the transporters of the SLC19 gene family are of great biological importance, and, therefore, disruptions of the functions of these transporters by genetic mutations can be expected to result in serious clinical complications.
Fig.1 Proposed transport mechanisms for the members of the SLC19 gene family. (Ganapathy, 2004)
Here show the three members of the SLC19 family of solute carriers: a folate transporter (SLC19A1) and two thiamine transporters (SLC19A2 and SLC19A3).
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
