Urea transporters (UTs), also known as solute carrier family 14 (SLC14), are a family of membrane proteins that transport urea molecules across cell membranes and play important roles in a variety of physiological processes, such as mediating the rapid and passive diffusion of urea down its concentration gradient. It has been reported that UTs are expressed in a wide variety of tissues, but their function is best understood in the kidney where they contribute to maintaining the high interstitial urea concentration necessary to limit the rate of water loss. In mammals, two types of urea transport proteins, UT-A and UT-B, have been identified. Particularly, the UT-A proteins are important for renal urea handling and are produced by alternative splicing of the SLC14A2 gene. What’s more, studies have shown that the majority of the variants of SLC14 transporters have 10 transmembrane domains, with a glycosylated extracellular loop at TM5/6, and intracellular C- and N-termini.
Here, we have described in detail of members of the SLC14, including SLC14A1 and SLC14A2. To learn more detailed information, please click the links below.
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