Corticotropin-releasing factor receptors (CRFRs), also known as corticotropin-releasing hormone receptors (CRHRs), are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH). Currently, there are two receptors in the family, termed CRHR1 and CRHR2, each encoded by a separate gene. Both of them are extensively distributed in the central nervous system (CNS) and the periphery. Studies have shown that CRHRs are important mediators in stress response. Cells in the anterior lobe of the pituitary gland known as corticotropes express the receptors and will secrete adrenocorticotropic hormone (ACTH) when stimulated. Moreover, it is recognized that the two subtypes of CRF receptor display quite different pharmacological profiles. To date, the expression of at least eight variants of CRFR1 mRNA (a, b, c, d, e, f, g and h) and three variants of CRFR2 mRNA (a, b, and c) has been detected and these alternative splicings were found to be regulated by diverse physiological and pathological factors in humans.
Here, we have listed all the members of the corticotropin-releasing factor receptor family, including corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. To learn more information about CRHR1 and CRHR2, please click the links below.
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