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Lysosome-associated Transmembrane Protein Family

Lysosome-associated transmembrane proteins (LAMPs) are type I transmembrane proteins characterized with a large, heavily glycosylated luminal domain, a transmembrane domain, and a short C-terminal cytoplasmic tail. They are the most abundant protein components of lysosome membranes which are initially considered to function as a barrier to protect lysosomal membranes from the lytic luminal environment, by forming a glycocalyx. Studies have shown that LAMPs are involved in diverse physiological processes, including lysosomal lumen acidification, cytoplasmic protein import, membrane fusion, and degraded product transportation to the cytoplasm. What’s more, they play important roles in maintaining lysosomal membrane integrity and phagolysosome formation.

Here, we have described in details of members of the lysosome-associated transmembrane family, including lysosomal-associated transmembrane protein 4B and lysosomal-associated transmembrane protein 5. To learn more detailed information, please click the links below.

Human Lysosome-associated Transmembrane Protein Members
LAPTM4B LAPTM5

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