Lysosome-associated transmembrane proteins (LAMPs) are type I transmembrane proteins characterized with a large, heavily glycosylated luminal domain, a transmembrane domain, and a short C-terminal cytoplasmic tail. They are the most abundant protein components of lysosome membranes which are initially considered to function as a barrier to protect lysosomal membranes from the lytic luminal environment, by forming a glycocalyx. Studies have shown that LAMPs are involved in diverse physiological processes, including lysosomal lumen acidification, cytoplasmic protein import, membrane fusion, and degraded product transportation to the cytoplasm. What’s more, they play important roles in maintaining lysosomal membrane integrity and phagolysosome formation.
Here, we have described in details of members of the lysosome-associated transmembrane family, including lysosomal-associated transmembrane protein 4B and lysosomal-associated transmembrane protein 5. To learn more detailed information, please click the links below.
Aided by our cutting-edge Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.