Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe organic solute transporter (OST) is one of the members of the solute carrier family and arguably one of the most unique. This transporter is composed of two gene products encoded by SLC51A and SLC51B that heterodimerize to form the functional OSTα-OSTβ complex. SLC51A encodes OSTα, a predicted 340-amino acid, 7-transmembrane (TM) domain protein, whereas SLC51B encodes OSTβ, a putative 128-amino acid, single-TM domain polypeptide. The beta subunit is required not only for heterodimerization and trafficking but also for function. This transporter is expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. Neither OSTα nor OSTβ alone has activity, but the two together transport a variety of substrates, including estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. Moreover, it can mediate either efflux or uptake via a facilitated diffusion mechanism, depending on the electrochemical gradient of its substrate. In polarized epithelial cells, OSTα-OSTβ protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids.
Here, we give a summary of the information of the two units of this complex regarding the structure, gene location, functions, phenotype of gene-deficient mice, and the recent findings.
Membrane proteins are notoriously difficult to investigate in isolation. The extraction, purification, and reconstitution of membrane proteins into an environment that partly resembles the native environment is vital to maintaining the stability and function of the target proteins. Here, aided by our powerful Magic™ membrane protein production platform, Creative Biolabs can reconstitute your proteins into many forms, which are classified detergent-assisted (detergent micelles, proteoliposomes, nanodiscs) and detergent-free methods (lipoparticles, and polymers). Our scientists know the advantages and drawbacks of each system well, leading to a wise decision on the selection of the optimal reconstitution system for specific downstream functional assays.
Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform to our clients where you can find the best-quality anti-membrane protein development services. We also present DNA immunization service for anti-membrane protein antibody development service for anti-membrane protein antibody development. For more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
