Potassium voltage-gated channel subfamily A belongs to the voltage-gated potassium channels (VGKCs) which are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential, primarily in the brain and the central nervous system. Generally, channel properties depend on the type of alpha subunits that are part of the channel. Studies have shown that they can form functional homotetrameric channels and heterotetrameric channels that contain different proportions of the VGKC subfamily A, such as KCNA1, KCNA2, KCNA4, and possibly other family members as well. During the past years, a broad range of physiological processes which depend on voltage-gated ion channels VGICs has been determined, including cellular signaling, control of muscle contraction, and ion homeostasis in non-excitable cells. What’s more, it has been reported that the VGKC subfamily A also contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability.
Here, we have described in details of members of the VGKC subfamily A, which including but not limited to potassium voltage-gated channel subfamily A member 1, potassium voltage-gated channel subfamily A member 2, and potassium voltage-gated channel subfamily A member 3. To learn more detailed information, please click the links below.
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