Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVoltage-gated potassium channels (Kv) play a vital role in regulating neuronal excitability, shaping action potentials, and modulating spike patterns. Mammalian neurons express a number of Kv channel subunits (>20), which are classified into 12 subfamilies based on their primary structures. They represent the largest and most diverse family of genes in the K+ channel family. Potassium voltage-gated channel subfamily B, also known as the Kv2 subfamily, is a family widely expressed in the central nervous system. It is composed of two members, namely potassium voltage-gated channel subfamily B member 1 (Kv2.1) and potassium voltage-gated channel subfamily B member 2 (Kv2.2), with a similar structure in N-terminal and membrane-spanning domains (90% homology). It has been reported that Kv2.2 is diffusely localized in the dendrites of cortical and hippocampal pyramidal neurons, whereas Kv2.1 is localized in large clusters in the somata and proximal dendrites. In particular, Kv2.1 is widely expressed in mammalian brain where it is responsible for the majority of the delayed rectifier current in many neurons.
Here, we have described in details of members of the VGKC subfamily B, including both potassium voltage-gated channel subfamily B member 1 and potassium voltage-gated channel subfamily B member 2. To learn more detailed information, please click the links below.
Based on our advanced MemDX™ membrane protein production platform, Creative Biolabs is committed to offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Furthermore, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
