Potassium voltage-gated channel subfamily V (KCNV protein family) represents the most complex class of voltage-gated ion channels from both functional and structural standpoints. The potassium voltage-gated channel subfamily V has diverse physiology functions, such as regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. In the past years, two members of the potassium voltage-gated channel subfamily V have been identified, namely potassium voltage-gated channel subfamily V member 1 (KCNV1) and potassium voltage-gated channel subfamily V member 2 (KCNV2). Studies have shown that KCNV1 is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. Whereas KCNV2 is strongly expressed in pancreas and has a weaker expression in several other tissues.
Here, we have described in details of members of the KCNV protein family, which includes potassium voltage-gated channel subfamily V member 1 and potassium voltage-gated channel subfamily V member 2. To learn more detailed information, please click the links below.
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