Solute carrier family 11 (SLC11), also known as natural resistance-associated macrophage proteins (NRAMPs), belongs to the “Amino acid-Polyamine-organoCation (APC)” superfamily, containing Na+- and H+-coupled secondary transporters and symporters, some of which are particularly well characterized, such as LeuT. SLC11 is composed of two transporters (SLC11A1/NRAMP1 and SLC11A2/NRAMP2) which both have 12 transmembrane regions and cytoplasmic N- and C- termini. Studies have suggested that SLC11A1 is expressed in the phagosomes of macrophages and it plays an essential role in host defense against pathogens. What’s more, it is also involved in the antimicrobial action in macrophages, although its precise mechanism is undefined. Whereas, SLC11A2 is more widely expressed and appears to assist in divalent cation assimilation from the diet, as well as in phagocytotic cells.
Here, we have described in detail of members of the SLC11 family, including SLC11A1and SLC11A2. To learn more detailed information, please click the links below.
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