Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs provide screening services for the CaVHHL-S2 Camel Synthetic Single Domain Antibody Library but does not sell the library directly. Our screening services enable users to discover high-affinity specific antibodies faster than traditional methods, improving both speed and efficiency during antibody discovery. Our advanced M13 pIII fusion phage display technology combined with high-throughput screening platforms enables clients to rapidly identify ideal antibody candidates while resolving issues like extended screening durations and the detection of low-affinity antibodies.
| Species | Camel | Library ID | CaVHHL-S2 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Synthetic VHH |
| Vector System | pMECS | Tags | HA, His tag |
| Library Capacity | 5.4×1010 | Randomization | Synthetic trimer-codon HCDR1, HCDR2 and HCDR3 |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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Synthetic Diversity The CaVHHL-S2 library contains entirely synthetic VHH fragments to produce a broad and varied antibody collection. The fully synthetic aspect of the library enables precise customization which improves antibody adaptability against numerous antigenic targets with unique or difficult traits. |
High Library Capacity The CaVHHL-S2 library contains a complete collection of potential antibody candidates. The vast diversity present in the library boosts the chances of discovering rare specific binders which is essential for precision-dependent applications. |
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SdAb Format SdAbs sourced from camelids demonstrate superior stability and durability under conditions of high heat, acidity and increased salt concentration. SdAbs become suitable for challenging antigens that evade other antibody formats through stable binding because they maintain high affinity and specificity. |
Efficient Phage Display System CaVHHL-S2 library's M13 pIII fusion phage display system enables efficient antibody candidate expression on phage surfaces which allows for quick and dependable screening. The system accelerates high-affinity binder discovery through optimization for antibody display and affinity maturation techniques. |
Our CaVHHL-S2 library screening service is designed to efficiently and effectively identify high-affinity, specific antibody candidates from the library. The system scales to deliver quick and trustworthy outcomes regardless of your needs for small exploratory projects or extensive high-throughput studies. Our service delivers quick and efficient screening solutions so you don't have to handle the screening process yourself. Our platform streamlines antibody discovery so you can concentrate on your research progress.
We offer comprehensive and customized antibody screening services through the CaVHHL-S2 Library, tailored to meet your unique project requirements. Our services cover a broad range of antibody types and target categories:
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
Include comprehensive details about your target such as protein, peptide, or small molecule. The screening process will be customized according to the unique properties of your target.
Using our CaVHHL-S2 Library, we conduct phage display-based screening to identify high-affinity, specific binders for your target. Our robust methodology ensures the selection of optimal candidates from an extensive library of synthetic sdAbs.
After completing the screening, we provide detailed results with candidate sdAb sequences and other key data, giving you all the necessary information to continue your project with confidence.
Our team of experts will provide continuous support throughout the screening process, addressing any questions or adjustments needed as you proceed with your antibody discovery.
Important Note: We only offer screening services and do not sell enriched libraries after multiple rounds of screening. Our primary focus is delivering high-quality screening results that meet the unique needs of your research or development project.
| Case: Screening for sdAbs that block target-ligand binding | |
| Objective | To select T1 binders from the CaVHHL-S2 sdAb Library that bind to the same epitope as the T1 ligand. |
| Starting Materials |
Target (T1): Protein of interest for antibody binding. T1 Ligand: Known ligand for T1 that binds to the target. Library: Premade CaVHHL-S2 Camel Synthetic Single Domain Antibody Library. |
| In-Solution Screening Strategy |
Pre-counter selection to deplete unspecific phages. Positive screening for the target T1. |
| Key Results |
  Blocking Activity: All 5 sdAb supernatants were able to block the binding of T1 to the ligand. Binding Inhibition: Demonstrated effective blocking of T1 binding epitope by the soluble sdAbs, confirming the presence of antibodies that bind to the same epitope as the T1 ligand. |
| Case: Screening for MHC-mutant peptide (Single amino acid mutation) complex | |
| Objective | To identify antibodies that specifically bind to a MHC-mutant peptide with a single amino acid mutation, distinguishing them from the wild-type MHC peptide. |
| Starting Materials |
Biotinylated target MHC-mutant peptide T1 Control MHC-wt peptide C1 Biotinylated control MHC-wt peptide C1 |
| In-Solution Screening Strategy |
Positive selection for biotinylated Target MHC-mutant peptide T1 Control MHC-peptide C1 as competitor to further remove the binders bound to control. |
| Key Results |
  Screening and Validation: 3 specific sdAbs were identified that selectively bind to the MHC-mutant peptide T1. Target Specificity: These sdAbs did not bind to the MHC-wild type peptide C1, demonstrating their ability to differentiate between the mutant and wild-type peptides based on the single amino acid mutation. |
Creative Biolabs presents multiple ready-to-use sdAb libraries obtained from camelids and humanized sdAbs. The libraries provide support for various research purposes including target discovery and therapeutic development. In addition, our collection also includes antibody libraries from various species such as mouse, rabbit, and chicken which allows you to select from a broad range of antibodies for your research work.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| CaVHHL-4 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.63×1010 | Screening-only |
| CaVHHL-5 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 3.0×1010 | Screening-only |
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CaVHHL-6 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.43×109 | ✔️ |
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CaVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 5.4×1010 | Screening-only |
| CaVHHL-S3 | pIII-fusion, Phagemid Phage Display | Synthetic VHH | 2.2×1010 | Screening-only |
| CaVHHL-S4 | pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | 5.3×1010 | Screening-only |
Creative Biolabs provides specialized antibody screening services which help accelerate research and development timelines with a commitment to high quality.
Let us accelerate your antibody discovery process. Contact us today for a custom quote and get started with our CaVHHL-S2 library screening service!
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
