Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe synthetic antibody library offers exceptional stability and specificity for diverse applications and why our services should become your choice for research needs. The CaVHHL-S3 Camel Synthetic Single Domain Antibody Library serves as a powerful tool to discover antibodies with both efficiency and quality. The library contains synthetic VHHs which deliver enhanced stability and specificity along with versatile use across drug discovery, diagnostics and immunotherapy fields. Our phage display screening services are designed to rapidly find high-affinity binders and produce faster and more dependable results. Our advanced platforms enable you to streamline research processes while speeding up therapeutic development to achieve optimal outcomes at reduced time and cost.
| Species | Camel | Library ID | CaVHHL-S3 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Synthetic VHH |
| Vector System | pCDisplay-3M | Tags | Myc, His tag |
| Library Capacity | 2.2×1010 | Randomization | Synthetic trimer-codon HCDR3 |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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Synthetic Diversity in CDRH3 The synthetic trimer-codon CDRH3 sequence generates diverse variability which strengthens the library's capacity to produce unique high-performing antibodies and improves the probability of identifying rare potent binders. |
Versatility for Challenging Targets Due to their small size and unique structure, sdAbs offer exceptional efficacy in targeting difficult antigen areas where conventional antibodies often face challenges in binding effectively. |
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High Specificity & Affinity Synthetic VHH domains demonstrate both high specificity and affinity across numerous antigens including small molecules and challenging membrane proteins which allows for precise identification of relevant binders for desired targets. |
Enhanced Stability sdAbs extracted from camelids demonstrate greater stability than typical antibodies and show enhanced resistance to heat, extreme pH levels, and denaturation conditions. SdAbs function well across multiple applications which encompass both therapeutic development and diagnostic processes. |
A reliable screening method is crucial to select superior candidates from an antibody library. Our advanced phage display screening platform guarantees the discovery of optimal binders tailored for your specific targets. Our customizable screening services enable us to adjust the process according to your specific research requirements which helps both speed up your project timeline and increase the accuracy of your results.
Our CaVHHL-S3 Library is ideal for a wide range of antibody screening applications. We offer comprehensive antibody screening services, including but not limited to the following categories:
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
Creative Biolabs offers a fast and reliable phage display screening process to efficiently identify the best binders for your targets. Here's how it works:
Describe your targets whether it is protein-based, peptide-based or a small molecule. Our screening process will be customized to meet your specific requirements.
Using our CaVHHL-S3 Library, we perform phage display screening to identify high-affinity binders. The process is customizable for different antibody formats and target types.
Once screening is complete, we deliver detailed results with antibody sequences and binding affinities, allowing you to quickly assess the best candidates.
Our support extends throughout the entire process as we help to answer your questions and keep your project on the right path.
Note: We specialize in screening-only services and do not provide enriched libraries. Our focus is on delivering high-quality results to identify the most promising candidates for your targets.
| Case: Screening for Anti-Soluble Protein sdAbs | |
| Starting Materials |
Target soluble protein T1 Control soluble protein C1, C2, and C3 |
| Solid-Phase Screening Strategy |
Pre-counter selection to deplete unspecific phages for C1, C2, and C3. Positive screening for the target protein T1. |
| Key Results |
  Five high-affinity sdAbs were identified from library screening and binder validation. Four out of five sdAbs exhibited high specificity for Antigen X, with minimal cross-reactivity to other proteins in the same family. |
Creative Biolabs offers a wide variety of sdAb libraries to support the different requirements of your research and development projects. Our collection features premade libraries that originate from camelids and humanized sdAbs which cater to multiple applications such as target identification and therapeutic advancement. We also provide other antibody format-based libraries derived from multiple species such as mouse, rabbit and chicken that offer extensive selection choices to fit your precise target needs. Creative Biolabs offers both ready-to-use libraries and customized phage display screening services through our high-quality specialized libraries to support every stage of your antibody discovery research.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| CaVHHL-4 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.63×1010 | Screening-only |
| CaVHHL-5 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 3.0×1010 | Screening-only |
|
CaVHHL-6 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.43×109 | ✔️ |
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CaVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 5.4×1010 | Screening-only |
| CaVHHL-S3 | pIII-fusion, Phagemid Phage Display | Synthetic VHH | 2.2×1010 | Screening-only |
| CaVHHL-S4 | pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | 5.3×1010 | Screening-only |
Ready to explore the potential of the CaVHHL-S3 library for your next project? today to learn more about our customizable antibody discovery services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
