Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe Phage Display CaVHHL-S4 Camel Semi-synthetic Single Domain Antibody Library is designed to help you overcome challenges in antibody development and identify high-affinity binders for your most difficult targets. Our tailored screening solutions leverage advanced phage display technology along with a diverse extensive antibody pool to efficiently fulfill your research requirements. Our antibody library provides high-specificity binders which help speed up your discovery process when working with complex proteins, low-immunogenic targets or unique biomarkers.
| Species | Camel | Library ID | CaVHHL-S4 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Semi-synthetic VHH |
| Vector System | pCDisplay-3M | Tags | Myc, His tag |
| Library Capacity | 5.3×1010 | Randomization | Introduced synthetic trimer-codon HCDR3 in naïve VHH gene pool (lacking HCDR3) |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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High Affinity and Specificity The CaVHHL-S4 Library provides antibodies that are highly specific and exhibit excellent binding affinity, making them ideal for therapeutic applications, diagnostic research, and various biotechnology applications. The single-domain structure allows for efficient penetration and binding, even to challenging and low-immunogenic targets such as membrane proteins and small molecules. |
Diverse, High-Quality Semi-Synthetic sdAbs This library combines the genetic diversity of naïve VHHs from camels with the introduction of synthetic trimer-codon HCDR3, enriching the gene pool that naturally lacks HCDR3. This semi-synthetic approach enhances the diversity and potential for high-affinity binders, improving the likelihood of identifying effective candidates for a wide range of targets. |
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Compact and Stable sdAbs SdAbs from the CaVHHL-S4 Library are known for their compact size and exceptional stability. Their unique properties enable these antibodies to be used across numerous applications including diagnostic testing and therapeutic creation under severe conditions. |
Versatile Screening Options Our CaVHHL-S4 Library is not just a library; it is a comprehensive solution. We offer customized screening services to isolate high-affinity binders for your targets, providing everything from initial screening to the final selection of optimal candidates. |
Creative Biolabs offers end-to-end antibody discovery solutions, from library access to custom screening. Our advanced phage display technology, coupled with the CaVHHL-S4 Library, ensures you get the best binders for your project, all while saving time and resources. The process is designed for scalability and efficiency, making it ideal for both small-scale exploratory screenings and large-scale high-throughput applications.
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
Provide us with detailed target information (e.g., protein, peptide, small molecule).
We conduct comprehensive phage display screening with the CaVHHL-S4 Library to identify high-affinity binders.
Receive detailed results with candidate antibody sequences and binding affinities.
Our team will provide continuous support throughout the screening process to ensure high-quality results.
Note: We provide screening-only services, and do not offer enriched libraries after multiple rounds of screening. Our focus is on providing you with high-quality screening results for your specific targets.
| Case: Screening for sdAbs Against Disease Targets | |
| Starting Materials | Target protein T1 (Caner antigen) |
| Solid-Phase Screening Strategy | We utilized a comprehensive in-solution phage display screening approach to identify high-affinity binders to the cancer antigen. |
| Key Results |
  Successfully identified several high-affinity sdAbs with strong binding to target T1, which were selected for further validation in in vitro cell-based assays to assess their potential for downstream applications. |
Creative Biolabs provides multiple premade sdAb libraries which originate from camelids and humanized sdAbs. Our customers can use these sdAb libraries for various applications that range from discovering targets to developing therapies. Our selection also includes other format of antibody libraries from various species such as mouse, rabbit, and chicken to ensure you have all the necessary antibodies for your research projects.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| CaVHHL-4 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.63×1010 | Screening-only |
| CaVHHL-5 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 3.0×1010 | Screening-only |
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CaVHHL-6 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.43×109 | ✔️ |
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CaVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 5.4×1010 | Screening-only |
| CaVHHL-S3 | pIII-fusion, Phagemid Phage Display | Synthetic VHH | 2.2×1010 | Screening-only |
| CaVHHL-S4 | pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | 5.3×1010 | Screening-only |
to learn more about how the CaVHHL-S4 Library can provide the perfect antibody solution for your project needs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
