Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe Phage Display HuVHHL-S1 Humanized Synthetic Single Domain Antibody Library serves as a leading resource to expedite the discovery of high-quality antibodies with exceptional specificity. Our library makes efficient identification of optimized drug candidates possible through the use of advanced humanization and randomization technologies together with a strong high-throughput screening platform. Our innovative approach accelerates antibody discovery while enhancing precision which leads to superior results in biopharmaceutical research.
| Library Type | Humanized Library | Library ID | HuVHHL-S1 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Humanized Synthetic VHH |
| Vector System | pMECS | Tags | HA, His tag |
| Library Capacity | >1.0×1011 | Randomization | Synthetic trimer-codon HCDR1, HCDR2 and HCDR3 |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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VHH Format - Compact and Robust VHHs provide better tissue penetration while being smaller and more stable than traditional antibodies which enables them to effectively target challenging antigens. Their inherent stability allows VHHs to function effectively under harsh conditions required for in vivo testing and industrial production. |
Humanized Design - Reduces Immunogenicity The humanized format reduces the potential for immune responses which enhances the safety of antibodies in clinical applications. A human-like design enables quick advancement from research stages to therapeutic applications while increasing clinical trial success rates. |
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High Randomization - Exceptional Diversity The library's synthetic method supports high diversity among its 1.0×1011 potential candidates. The strategic randomization of crucial HCDR regions improves the probability of discovering antibodies that exhibit both high affinity and exceptional specificity for your target. |
Accelerated Screening - Direct Access to Humanized Antibodies Researchers can achieve quicker humanized VHH antibody screenings with the HuVHHL-S1 Library which streamlines the early discovery process. The generation time for therapeutic-grade candidates drops which speeds up the development process. |
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Customizable Screening - Tailored to Your Needs Our high-throughput screening platform can adapt to multiple target types including proteins, peptides, and small molecules so you can effectively select the optimal antibody candidates for your research or therapeutic purposes. |
Excellent Project Success Rate HuVHHL-S1 Library has established itself as highly reliable because numerous clients have moved their antibody candidates through to pre-clinical and clinical testing phases. Success rates in therapeutic development reach their maximum potential through the combined use of humanization, randomization and robust screening methods. |
The HuVHHL-S1 Library enables rapid identification of specific antibodies that target various complex biological molecules. The humanized library format removes the requirement for additional humanization steps which often slow down therapeutic antibody development. Our approach begins with humanized VHH antibodies to make the discovery simpler while speeding up the timeline which leads to quicker advances from screening research to clinical use.
We offer phage display screening services that you can tailor to fit your exact research requirements. Our process can be customized to accommodate different target classes regardless of your research focus on therapeutic development, biomarker identification or diagnostic assays. We also specialize in developing antibodies for bispecific and anti-epitope formats, as well as cell-internalizing antibodies to enhance the specificity and functionality of your therapeutic candidates.
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors |
| Receptor Targets and Toxin Targets | Disease and Biomarker Targets | Cancer Antigens and Pathogen-derived Antigens |
To simplify the screening process, we offer a comprehensive, seamless workflow designed to save you time and effort while delivering high-quality antibody candidates tailored for your research or therapeutic needs.
Provide us with your antigen details (recombinant protein, peptide, small molecule, cells, etc.) for initial screening.
We perform multi-round biopanning using the HuVHHL-S1 library under optimized conditions to ensure high-affinity binders are selected.
After screening, we deliver a detailed report including VHH sequences, binding data (e.g., ELISA or SPR), and clone information.
Our expert scientific team provides ongoing guidance to help you validate and optimize the antibody candidates for your specific application, be it therapeutic or diagnostic.
Please note: We provide screening-only services and do not supply enriched phage pools after panning. This approach allows us to concentrate on delivering high-quality, sequence-defined antibody candidates that are specifically optimized for downstream applications.
| Case: Development of Neutralizing sdAbs Against a Viral Antigen | |
| Objective | To identify neutralizing sdAbs targeting a viral antigen, Viral Protein T1, using the Phage Display HuVHHL-S1 Humanized Synthetic sdAb Library. The goal was to develop high-affinity neutralizing sdAbs for potential use in therapeutic applications against viral infections. |
| Starting Materials | Viral Protein T1, the key viral protein responsible for binding to the receptor on host cells, enabling viral entry. |
| In-Solution Screening Strategy |
Pre-selection steps were implemented to remove nonspecific binders before initiating the main screening process. Positive screening was conducted with four rounds of biopanning. Competition-based screening to identify sdAbs capable of inhibiting T1 binding to the receptor. |
| Key Results |
  Following four rounds of screening, several sdAb clones were identified that bound specifically to the T1. Subsequent internal validation by the customer confirmed that one particular clone exhibited strong neutralizing activity. This clone effectively blocked the interaction between T1 and its receptor in cell-based assays, successfully preventing viral entry into host cells. |
Creative Biolabs offers a comprehensive selection of premade sdAb libraries derived from camel, alpaca, and humanized sources. Available in both synthetic and natural formats, these libraries are designed to support a wide array of research applications, from target discovery to therapeutic development. Our expert screening services help identify high-affinity binders, ensuring reliable and accurate results. We also offer flexible licensing options, allowing you to integrate our libraries into your own research and product development with ease.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
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HuVHHL-S1 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | >1.0×1011 | Screening-only |
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HuVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | >1.0×1010 | Screening-only |
Contact us for more information on how our libraries and screening platforms can help you achieve your research goals!
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
