Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe Phage Display LlaVHHL-S1 Llama Synthetic Single Domain Antibody Library enables you to streamline antibody discovery, obtain high-affinity sdAbs, and overcome key bottlenecks in your drug development pipeline. sdAbs are small, stable, and highly specific - ideal for targeting challenging antigens, penetrating tissues, and enabling innovative therapeutic or diagnostic formats. Our pre-made synthetic VHH library, powered by advanced phage display and trimer-codon randomization, offers massive diversity and compatibility with high-throughput screening - allowing for rapid, reliable selection of binders without animal immunization, saving time and accelerating your path to breakthrough results.
| Species | Llama | Library ID | LlaVHHL-S1 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Synthetic VHH |
| Vector System | pMECS | Tags | HA, His tag |
| Library Capacity | 1.5×1011 | Randomization | Synthetic trimer-codon HCDR1, HCDR2 and HCDR3 |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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Unmatched Diversity The LlaVHHL-S1 Library offers a broad selection of potential antibody candidates through its extensive synthetic VHH variants collection. The extensive diversity within the library increases the chances of finding high-affinity binders that match your particular target including proteins pathogen or receptors. |
Synthetic Design for Consistency The LlaVHHL-S1 library stands out because its synthetic engineering approach eliminates biases associated with host animals unlike traditional antibody libraries. The design provides consistent and reproducible outcomes without the variability found in animal immune responses. |
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Superior Affinity and Specificity Llama-derived VHHs stand out because they exhibit remarkable binding affinity and specificity. Their distinct structure makes it possible for them to accurately target challenging antigens including small proteins and low molecular weight compounds which exhibit poor immunogenicity. |
Small Size, Big Advantage VHHs possess a much smaller structure than regular antibodies which results in enhanced tissue penetration capabilities. The small size of these molecules enables them to reach hard-to-access epitopes within tumors and intracellular targets which makes them prime candidates for future drug delivery systems and therapeutic solutions. |
The LlaVHHL-S1 Library from Creative Biolabs offers efficient, scalable phage display screening that accelerates antibody discovery across diverse targets. Our streamlined platform provides fast, accurate, and reproducible results, reducing internal workload and maximizing discovery potential. By managing library handling, panning, and analysis, we allow you to focus on data interpretation and application. Integrated with expert assay design and advanced phage display technology, our service quickly identifies high-affinity sdAbs for research, diagnostics, and therapeutic development.
LlaVHHL-S1 library-based screening services are fully customizable to meet the specific biological context and target class of your project. We specialize in the discovery of functionally relevant sdAbs against a wide array of molecular and cellular targets.
| Antibody Formats Available: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Compatible Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Pathogen-derived Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
Provide antigen information (recombinant protein, peptide, small molecule, cells, etc.).
We perform multi-round biopanning using the LlaVHHL-S1 library under optimized conditions.
You receive detailed deliverables including VHH sequences, binding data (e.g., ELISA/SPR), and other information.
Our scientific team offers continuous guidance for candidate validation and application development.
Note: We offer screening-only services and do not provide enriched phage pools post-panning. This ensures a clear focus on delivering quality-controlled, sequence-defined antibody candidates optimized for downstream applications.
| Case: Library Screening Against Target Proteins from Different Species | |
| Objective | To identify high-affinity cross-reactive sdAbs against human, mouse, and monkey target proteins T1 (hT1, mT1, cynoT1) using our LlaVHHL-S1 Library. |
| Starting Materials | Human, mouse, monkey target proteins huT1, mT1, cynoT1 |
| In-Solution Screening Strategy |
Pre-counter selection to deplete unspecific phages. Positive screening for the targets, with two rounds of biopanning for hT1 and mT1. |
| Key Results |
  After four rounds of screening for both human (hT1) and mouse (mT1) targets, we identified a significant enrichment of clones with high binding affinity for both species. Furthermore, 10 unique sequences specifically binding to human and mouse T1 were validated through phage ELISA and sequencing. Soluble ELISA further confirmed the strong binding capacity of these clones, underscoring the success of our screening process in identifying high-affinity, species-cross-reactive sdAbs targeting human, mouse, and monkey T1. |
Creative Biolabs provides an extensive range of premade sdAb libraries sourced from camel, alpaca, llama, and humanized sdAbs. Available in both synthetic and natural formats, these libraries are tailored to meet diverse research needs, from target discovery to therapeutic development. Our expert screening services facilitate the identification of high-affinity binders, ensuring precise and reliable results. Additionally, we offer Licensing-out options, granting you flexible access to our designated libraries for integration into your own research and product development.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
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LlaVHHL-1 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 1.9×1010 | ✔️ |
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LlaVHHL-2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 1.8×1010 | Screening-only |
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LlaVHHL-S1 �� Highly Recommended |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 1.5×1011 | Screening-only |
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LlaVHH-YPD-1 ⚡️ Hot Product |
Yeast Display | Naïve VHH | 1.5×108 | ✔️ |
for more information on how our libraries and screening platforms can help you achieve your research goals!
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
