Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe CaVHHL-4 Camel Naïve sdAb Antibody Library is an advanced and powerful resource for researchers seeking efficient and precise antibody screening. Sourced from 15 non-immunized camels, this library provides an extensive collection of high-quality naïve sdAb antibodies, offering unique access to high-affinity binders for a broad range of targets. Powered by a robust phage display system and a large library capacity, the CaVHHL-4 Library maximizes your chances of finding the perfect antibody for your research needs.
| Species | Camel | Library ID | CaVHHL-4 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Naïve VHH |
| Vector System | pCDisplay-3M | Tags | Myc, His tag |
| Library Capacity | 2.63×1010 | Library Source | Collections of antibody genes from 15 none immunized camels |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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Exceptional Screening Performance The CaVHHL-4 Library offers outstanding screening results, providing accurate and reliable identification of high-affinity sdAbs for a wide range of protein targets. Its advanced screening process ensures you receive precise and actionable results to drive your research forward. |
Wide Range of Target Compatibility Our custom screening services are designed to meet the unique needs of your project. Whether you're working with protein targets, low-immunogenic antigens, or challenging epitopes, the CaVHHL-4 Library offers a highly flexible solution that accommodates diverse target types with remarkable accuracy. |
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Unique Camel Antibody Source Creative Biolabs generates the CaVHHL-4 Library by extracting naïve sdAbs taken from camels that had not undergone immunization. This technique vastly increases the number of available binders which permits us to access challenging epitopes and antigens with low immunogenicity. The small size, high stability and strong specificity of camel-derived sdAbs make them superior for rapid and efficient screening when compared to traditional immunization-based methods. |
Scalable & Rapid Screening The CaVHHL-4 Library utilizes its substantial library capacity to enable scalable high-throughput screening processes. The method enables swift detection of strong-binding sdAbs without sacrificing result precision and quality. The streamlined screening process helps you to rapidly find top candidates which speeds up your antibody discovery workflow. |
Submit complete details about your investigational target which can be a protein, peptide, small molecule or cell-based target. Specify any particular conditions or requirements that will customize the screening process to match your needs.
Using the CaVHHL-4 Library and phage display technology, we perform rapid, high-throughput screening to identify high-affinity binders that meet your specific criteria.
We deliver a comprehensive detailed report post-screening that lists the top candidate sequences along with their binding affinity and specificity to provide you with the necessary information for advancing your research.
We provide ongoing support by helping you interpret data and guiding you through future analysis stages or project directions.
Important Note: We specialize in screening-only services and do not offer enriched libraries after multiple rounds of screening. Our focus is on delivering high-quality, actionable results for your specific targets.
We provide a comprehensive suite of screening services to meet the diverse needs of your research projects. Our capabilities include, but are not limited to:
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
| Case: Screening for Specific sdAbs Against Target Protein | |
| Starting Materials |
Target Protein T1 Control Protein C1 |
| In-Solution Screening Strategy |
Pre-counter selection using control antibody C1 Positive selection for target antibody T1 |
| Key Results |
  After four rounds of screening and validating 92 randomly cloned phages through ELISA, we successfully identified 3 candidate clones with specific binding to the target protein T1. These clones were further validated for cross-reactive properties using soluble ELISA. The results showed that we obtained two specific clones which do not bind to control protein C1. |
Looking for even more options in antibody discovery? We offer an extensive selection of premade sdAb libraries, which are listed below. You can freely choose from these libraries and take advantage of our customized screening services or explore licensing opportunities. In addition, we provide other formats sourced from human, mouse, and rabbit, catering to both research and commercial applications. These libraries offer a broad range of options, allowing you to select the best fit for your specific project needs and accelerate your antibody discovery process.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| CaVHHL-4 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.63×1010 | Screening-only |
| CaVHHL-5 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 3.0×1010 | Screening-only |
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CaVHHL-6 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.43×109 | ✔️ |
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CaVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 5.4×1010 | Screening-only |
| CaVHHL-S3 | pIII-fusion, Phagemid Phage Display | Synthetic VHH | 2.2×1010 | Screening-only |
| CaVHHL-S4 | pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | 5.3×1010 | Screening-only |
Are you prepared to speed up your antibody discovery process? , and we will assist you in beginning your work with the CaVHHL-4 library. We will equip you with the necessary tools and scientific expertise to help you achieve your scientific goals.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
