Voltage-gated potassium (KV) channels are crucial regulators of cell excitability. They allow potassium to flow along its electrochemical gradient upon depolarization of the plasma membrane. Potassium voltage-gated channel subfamily H (KCNH channels) forms an important family of voltage-gated potassium channels. Studies have shown that the KCNH potassium channels have the characteristic tetrameric organization of voltage-gated channels. Currently, eight subunits of the KCNH protein family have been discovered and denoted KCNH1-8. Each subunit has six trans-membrane helices where the first four form the voltage-sensor domain and the last two, together with equivalent regions from the other three subunits, compose the channel pore. They share a relatively negative activation threshold and are open at 0 mV, raising the possibility that coupling between the voltage-sensing and permeation modules may be required to maintain the channel closed, rather than to open the gate. Most importantly, the KCNH potassium channels play important roles in diverse physiological processes, such as cardiac repolarization, neuronal excitability, cell differentiation, and tumor growth.
Here, we have described in details of members of the VGKC subfamily H, which including but not limited to potassium voltage-gated channel subfamily H member 1, potassium voltage-gated channel subfamily H member 2, and potassium voltage-gated channel subfamily H member 3. To learn more detailed information, please click the links below.
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