Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsVoltage-gated potassium (KV) channels are crucial regulators of cell excitability. They allow potassium to flow along its electrochemical gradient upon depolarization of the plasma membrane. Potassium voltage-gated channel subfamily H (KCNH channels) forms an important family of voltage-gated potassium channels. Studies have shown that the KCNH potassium channels have the characteristic tetrameric organization of voltage-gated channels. Currently, eight subunits of the KCNH protein family have been discovered and denoted KCNH1-8. Each subunit has six trans-membrane helices where the first four form the voltage-sensor domain and the last two, together with equivalent regions from the other three subunits, compose the channel pore. They share a relatively negative activation threshold and are open at 0 mV, raising the possibility that coupling between the voltage-sensing and permeation modules may be required to maintain the channel closed, rather than to open the gate. Most importantly, the KCNH potassium channels play important roles in diverse physiological processes, such as cardiac repolarization, neuronal excitability, cell differentiation, and tumor growth.
Here, we have described in details of members of the VGKC subfamily H, which including but not limited to potassium voltage-gated channel subfamily H member 1, potassium voltage-gated channel subfamily H member 2, and potassium voltage-gated channel subfamily H member 3. To learn more detailed information, please click the links below.
Aided by our advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
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