Serine incorporator, also known as SERINC proteins, is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. These proteins are highly conserved and unique and are not homologous with other eukaryotic proteins, which possibly makes their function in the cell membrane indispensable. To date, five members (from SERINC1 to SERINC5) of the SERINC family have been identified. Studies have shown that SERINC proteins participate in the transport of the serine amino acid through the lipid bilayer and in the biosynthesis of sphingolipids and phosphatidylserine by incorporating serine into membrane lipids.
Here, we have described in detail of members of the serine incorporator family, which including serine incorporator 1, serine incorporator 3, and serine incorporator 5. To learn more detailed information, please click the links below.
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