Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe solute carrier family 46 (SLC46) has been reported to transport folic acid and its derivatives, and heme with lower affinity. Besides, some of the SLC46s in mammals and flies appear to promote muropeptides delivery and recognition. A study has been reported SLC46 can promote cytosolic innate immune recognition of monomeric peptidoglycans. Furthermore, mammalian SLC46As also facilitate TCT- and MDP-triggered NOD receptor activation in human epithelial cells.
There have two common members of SLC46, including SLC46A1 and SLC46A2. SLC46A1 encoded by the SLC46A1 gene promotes the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments, responsible for the intestinal absorption of folate and antifolates. Besides, SLC46A1 protein may also act as a heme transporter in duodenal enterocytes. Mutations in SLC46A1 gene are related to autosomal recessive hereditary folate malabsorption disease. Furthermore, mammalian SLC46A2s promote TCT-triggered NOD1 activation in human epithelial cell lines, indicating that SLC46As is a conserved group of peptidoglycan transporter contributing to cytosolic immune recognition. Here, we have described in detail of members of the SLC46. To learn more detailed information, please click the links below.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
