Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAs an excellent service provider in premade antibody library screening, Creative Biolabs offers high quality antibody discovery service for global customers. According to customer's detailed requirements, we are able to screen numerous specific antibodies against the custom targets, using our plentiful premade library resources. With our vast experience and well-established platform, we are confident in screening specific anti-PTM antibody for global multiple applications.
Post-translational modifications (PTMs) of proteins, including methylation, acetylation, phosphorylation, glycosylation and ubiquitination, play key roles in many biological processes, such as cell signaling, gene transcription regulation, protein degradation and cell-cell adhesion. Also, PTMs is associated with diseases such as cancer. Thus, identification and quantification of PTMs are critical for a fundamental understanding of cell biology and for elucidating disease mechanisms. During the past, anti-PTM antibodies have been used as the specific reagents to analyze the existence or relative amounts of the modified protein or to more quantitatively characterize cell populations bearing the modification of interest.
Fig.1 The role of post-translational modification (PTM) in translocation and immune activation by HMGB1. (Richard, 2017)
Generally, anti-PTM antibodies are produced by animal immunization methods. However, affinity and specificity among different antibody products to the same PTM vary significantly. In addition, most of current antibodies to PTMs are polyclonal antibodies that cannot be reproduced, which bringing a serious impediment in obtaining reproducible and reliable data. With years of experience in antibody production, Creative Biolabs has established advanced phage display platforms, which enables us to identify specific anti-PTM antibodies from our large naïve, immunized and synthetic libraries with affinity ranging from pM to nM. According to your novel requirement, our experienced scientists will tailor biopanning strategy to increase of candidates with higher affinity and desired specificity. Premade phage displayed antibody libraries in Creative Biolabs include:
| Libraries | Library ID | Display Technology | Library Format | Species | Library Size |
| Phage display human scFv libraries | HuScL-2 | Phage Display | scFv | Human | 1.42×109 |
| HuScL-4 | Phage Display | scFv | Human | 2.0×109 | |
| HuScL-6 | Phage Display | scFv | Human | 1.0×1011 | |
| HuScL-7 | Phage Display | scFv | Human | 1.1×1010 | |
| Phage display human Fab libraries | HuFabL-4 | Phage Display | Fab | Human | 1.9×1010 |
| HuFabL-5 | Phage Display | Fab | Human | 1.1×1010 | |
| HuFabssL-1 | Phage Display | Fab | Human | 1.8×1010 |
Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:
In terms of years of experience in phage display realm, Creative Biolabs has served our global clients with high-quality library screening services. Our scientists are confident in tailoring the most reliable and cost-effective protocol to facilitate worldwide researchers' programs. Except for anti-PTM antibody, we also offer premade phage displayed antibody library screening services for TCR-like and anti-Id antibody discovery. Learn more about our premade antibody library screening service, please feel free to contact us.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
