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Anti-Tumor-Specific Target Antibody Discovery from Premade Phage Displayed Antibody Library

Creative Biolabs is one of the world-leading experts who is professional in applying advanced phage display technologies for both therapeutic and regent antibody discovery. With years of experience, our scientists can offer comprehensive premade antibody library screening services to meet our clients’ demands precisely. Particularly, our services also involve specific antibody discovery against tumor-specific targets.

Anti-Tumor-Specific Target Antibody

Since the development of hybridoma technology, antibody-based therapeutics have developed rapidly. Recently, advances in antibody engineering and the development of chimeric, humanized, and fully human monoclonal antibody (mAbs) have led to the explosive increase of tumor antigen (TA)-targeting antibodies, which may target tumor cells by engaging surface antigens differentially expressed in cancers. As a growing family of novel molecules applied in the treatment of solid and hematological cancers, anti-tumor-specific target antibodies interact with components of the immune system through antibody-dependent-cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Furthermore, the long half-life, low toxicity, and high affinity and specificity make them attractive potential therapeutic agents.

Anti-Tumor-Specific Target Antibody Discovery from Premade Phage Displayed Antibody LibraryFig.1 Antibody therapy of cancer (Andrew M. Scott, et al, 2012)

Premade Phage Displayed Antibody Library Screening for Anti-Tumor-Specific Target Antibody

Phage display technology has been widely used in the process of antibody development. During the past decades, Creative Biolabs has constructed a comprehensive package of naïve and synthetic phage display antibody libraries for numerous antibody discovery. Aided by our professional scientists, we are able to tailor a customized biopanning strategy to discover impeccable binder which is able to recognize the naïve targets. We are confident in making your project a success. The premade phage displayed antibody libraries in Creative Biolabs include:

Libraries Library ID Display Technology Library Format Species Library Size
Phage display human scFv libraries HuScL-2 Phage Display scFv Human 1.42×109
HuScL-4 Phage Display scFv Human 2.0×109
HuScL-6 Phage Display scFv Human 1.0×1011
HuScL-7 Phage Display scFv Human 1.1×1010
Phage display human Fab libraries HuFabL-4 Phage Display Fab Human 1.9×1010
HuFabL-5 Phage Display Fab Human 1.1×1010
HuFabssL-1 Phage Display Fab Human 1.8×1010


Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:


Advantages of Our Service


As an industrial leader specialized in antibody discovery, Creative Biolabs provides premade phage displayed antibody library. Screening service for numerous anti-disease-specific target antibodies discovery, which including but not limited to anti-tumor-specific target antibody. Our professional scientists are glad to provide a one-stop custom service of premade library screening against various targets. Please contact us to learn more about how we can aid your project.

Reference

  1. Andrew M. Scott, et al, 2012. Antibody therapy of cancer. Nature Reviews Cancer, volume 12, P278-287.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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