CD20

CD20 (Cluster of Differentiation 20), also called B lymphocyte antigen CD20, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells, in human it is encoded by MS4A1 gene. CD20 plays a role in the development and differentiation of B-cells into plasma cells.its function is to enable optimal B-cell immune response, specifically against T-independent antigens.CD20 is expressed on all stages of B cell development except the first and last. It has been found that associated with B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. Therefore CD20 have been considered as a therapeutic target of monoclonal antibodies such as rituximab, obinutuzumab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC227 NK cell Second ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC354 T cell ~8kb Lentiviral scFv-41BB-CD3ζ/Her2t Human Inquiry
CAR-MZ017 T cell First Leu-16 ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-MZ018 T cell Third Leu-16 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-MZ055 NK cell First Ofatumumab ~8kb Lentiviral scFv-FcγRIII Human Inquiry
CAR-MZ056 NK cell First Ofatumumab ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-MZ057 NK cell Second Ofatumumab ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ058 NK cell Second Ofatumumab ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-NK-1-M327-2 NK cell First rituximab 8kb Lentiviral scFv-CD28 Chimeric Inquiry
CAR-NK-1-M327-G NK cell First rituximab 8kb Lentiviral scFv-FcεRIγ Chimeric Inquiry
CAR-NK-1-M327-Z NK cell First rituximab 8kb Lentiviral scFv-CD3ζ Chimeric Inquiry
CAR-NK-2-M327-2Z NK cell Second rituximab 8kb Lentiviral scFv-CD28-CD3ζ Chimeric Inquiry
CAR-NK-2-M327-4G NK cell Second rituximab 8kb Lentiviral scFv-CD4-FcεRIγ Chimeric Inquiry
CAR-NK-2-M327-4Z NK cell Second rituximab 8kb Lentiviral scFv-CD4-CD3ζ Chimeric Inquiry
CAR-NK-2-M327-8Z NK cell Second rituximab 8kb Lentiviral scFv-CD8-CD3ζ Chimeric Inquiry
CAR-NK-2-M327-BG NK cell Second rituximab 8kb Lentiviral scFv-CD28-FcεRIγ Chimeric Inquiry
CAR-NK-2-M327-BZ NK cell Second rituximab 8kb Lentiviral scFv-41BB-CD3ζ Chimeric Inquiry
CAR-NK-2-M327-CZ NK cell Second rituximab 8kb Lentiviral scFv-b2c-CD3ζ Chimeric Inquiry
CAR-NK-3-M327-2BZ NK cell Third rituximab 8kb Lentiviral scFv-CD28-41BB-CD3ζ Chimeric Inquiry
CAR-NK-3-M327-2XZ NK cell Third rituximab 8kb Lentiviral scFv-CD28-OX40-CD3ζ Chimeric Inquiry
CAR-T-1-M302-2 T cell First 1F5 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M302-G T cell First 1F5 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M302-Z T cell First 1F5 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-M302-2G T cell Second 1F5 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M302-2Z T cell Second 1F5 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M302-4G T cell Second 1F5 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M302-4Z T cell Second 1F5 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M302-8Z T cell Second 1F5 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M302-BZ T cell Second 1F5 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M302-CZ T cell Second 1F5 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-M302-2BZ T cell Third 1F5 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M302-2XZ T cell Third 1F5 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C034Z CD20 Human A64 Human ~8kb Lentiviral SLFLGILSV Soluble T-cell receptor HLA-A2 Inquiry
TCR-L129 CD20 Human A94 Human ~8kb Lentiviral SLFLGILSV Soluble T-cell receptor HLA-A2 Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC341 1F5 Lentivirus First scFv (1F5)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC342 1F5 Lentivirus First scFv (1F5)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC343 1F5 Lentivirus First scFv (1F5)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC344 1F5 Lentivirus Second scFv (1F5)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC345 1F5 Lentivirus Second scFv (1F5)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC346 1F5 Lentivirus Second scFv (1F5)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC347 1F5 Lentivirus Second scFv (1F5)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC348 1F5 Lentivirus Second scFv (1F5)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC349 1F5 Lentivirus Second scFv (1F5)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC350 1F5 Lentivirus Second scFv (1F5)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC351 1F5 Lentivirus Third scFv (1F5)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC352 1F5 Lentivirus Third scFv (1F5)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC746 Leu-16 Lentivirus First scFv (Leu-16)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC747 Leu-16 Lentivirus Second scFv (Leu-16)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC769 Ofatumumab Lentivirus First scFv (Ofatumumab)-FcγRIII CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC770 Ofatumumab Lentivirus First scFv (Ofatumumab)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC771 Ofatumumab Lentivirus Second scFv (Ofatumumab)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC772 Ofatumumab Lentivirus Second scFv (Ofatumumab)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C311 Human A64 Human Lentivirus SLFLGILSV Soluble T-cell receptor > 10⁷ IFU/ml Inquiry
VP-TCR-C312 Human A94 Human Lentivirus SLFLGILSV Soluble T-cell receptor > 10⁷ IFU/ml Inquiry
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