Anti-CD20 CAR Products - Creative Biolabs

CD20

CD20 (Cluster of Differentiation 20), also called B lymphocyte antigen CD20, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells, in human it is encoded by MS4A1 gene. CD20 plays a role in the development and differentiation of B-cells into plasma cells.its function is to enable optimal B-cell immune response, specifically against T-independent antigens.CD20 is expressed on all stages of B cell development except the first and last. It has been found that associated with B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. Therefore CD20 have been considered as a therapeutic target of monoclonal antibodies such as rituximab, obinutuzumab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias.

Associated Disease

Chronic lymphocytic leukemia (CLL)
Non-Hodgkin’s lymphoma (NHL)
Relapsed indolent B-cell and mantle cell lymphomas
Recurrent/refractory CD20+ lymphoma
Others

Vector Products
Viral Particles

CAR Vector Products Product list:

Catalog	Targeting Cell Type	Generation	Antibody Clone	Vector Length	Vector Type	Vector Design	Antibody Host	Data sheet	Price
CAR-LC227	NK cell	Second		~8kb	Lentiviral	scFv-41BB-CD3ζ	Mouse		Inquiry
CAR-LC354	T cell			~8kb	Lentiviral	scFv-41BB-CD3ζ/Her2t	Human		Inquiry
CAR-MZ017	T cell	First	Leu-16	~8kb	Lentiviral	scFv-CD3ζ	Human		Inquiry
CAR-MZ018	T cell	Third	Leu-16	~8kb	Lentiviral	scFv-CD28-41BB-CD3ζ	Mouse		Inquiry
CAR-MZ055	NK cell	First	Ofatumumab	~8kb	Lentiviral	scFv-FcγRIII	Human		Inquiry
CAR-MZ056	NK cell	First	Ofatumumab	~8kb	Lentiviral	scFv-CD3ζ	Human		Inquiry
CAR-MZ057	NK cell	Second	Ofatumumab	~8kb	Lentiviral	scFv-CD28-CD3ζ	Human		Inquiry
CAR-MZ058	NK cell	Second	Ofatumumab	~8kb	Lentiviral	scFv-41BB-CD3ζ	Human		Inquiry
CAR-NK-1-M327-2	NK cell	First	rituximab	8kb	Lentiviral	scFv-CD28	Chimeric		Inquiry
CAR-NK-1-M327-G	NK cell	First	rituximab	8kb	Lentiviral	scFv-FcεRIγ	Chimeric		Inquiry
CAR-NK-1-M327-Z	NK cell	First	rituximab	8kb	Lentiviral	scFv-CD3ζ	Chimeric		Inquiry
CAR-NK-2-M327-2Z	NK cell	Second	rituximab	8kb	Lentiviral	scFv-CD28-CD3ζ	Chimeric		Inquiry
CAR-NK-2-M327-4G	NK cell	Second	rituximab	8kb	Lentiviral	scFv-CD4-FcεRIγ	Chimeric		Inquiry
CAR-NK-2-M327-4Z	NK cell	Second	rituximab	8kb	Lentiviral	scFv-CD4-CD3ζ	Chimeric		Inquiry
CAR-NK-2-M327-8Z	NK cell	Second	rituximab	8kb	Lentiviral	scFv-CD8-CD3ζ	Chimeric		Inquiry
CAR-NK-2-M327-BG	NK cell	Second	rituximab	8kb	Lentiviral	scFv-CD28-FcεRIγ	Chimeric		Inquiry
CAR-NK-2-M327-BZ	NK cell	Second	rituximab	8kb	Lentiviral	scFv-41BB-CD3ζ	Chimeric		Inquiry
CAR-NK-2-M327-CZ	NK cell	Second	rituximab	8kb	Lentiviral	scFv-b2c-CD3ζ	Chimeric		Inquiry
CAR-NK-3-M327-2BZ	NK cell	Third	rituximab	8kb	Lentiviral	scFv-CD28-41BB-CD3ζ	Chimeric		Inquiry
CAR-NK-3-M327-2XZ	NK cell	Third	rituximab	8kb	Lentiviral	scFv-CD28-OX40-CD3ζ	Chimeric		Inquiry
CAR-T-1-M302-2	T cell	First	1F5	8kb	Lentiviral	scFv-CD28	Mouse		Inquiry
CAR-T-1-M302-G	T cell	First	1F5	8kb	Lentiviral	scFv-FcεRIγ	Mouse		Inquiry
CAR-T-1-M302-Z	T cell	First	1F5	8kb	Lentiviral	scFv-CD3ζ	Mouse		Inquiry
CAR-T-2-M302-2G	T cell	Second	1F5	8kb	Lentiviral	scFv-CD28-FcεRIγ	Mouse		Inquiry
CAR-T-2-M302-2Z	T cell	Second	1F5	8kb	Lentiviral	scFv-CD28-CD3ζ	Mouse		Inquiry
CAR-T-2-M302-4G	T cell	Second	1F5	8kb	Lentiviral	scFv-CD4-FcεRIγ	Mouse		Inquiry
CAR-T-2-M302-4Z	T cell	Second	1F5	8kb	Lentiviral	scFv-CD4-CD3ζ	Mouse		Inquiry
CAR-T-2-M302-8Z	T cell	Second	1F5	8kb	Lentiviral	scFv-CD8-CD3ζ	Mouse		Inquiry
CAR-T-2-M302-BZ	T cell	Second	1F5	8kb	Lentiviral	scFv-41BB-CD3ζ	Mouse		Inquiry
CAR-T-2-M302-CZ	T cell	Second	1F5	8kb	Lentiviral	scFv-b2c-CD3ζ	Mouse		Inquiry
CAR-T-3-M302-2BZ	T cell	Third	1F5	8kb	Lentiviral	scFv-CD28-41BB-CD3ζ	Mouse		Inquiry
CAR-T-3-M302-2XZ	T cell	Third	1F5	8kb	Lentiviral	scFv-CD28-OX40-CD3ζ	Mouse		Inquiry

TCR Vector Products Product list:

Catalog	Target	Target Species	Antibody Clone	scFv-Host Animal	Vector length	Vector Type	Epitope	Format	HLA	Data sheet	Price
TCR-C034Z	CD20	Human	A64	Human	~8kb	Lentiviral	SLFLGILSV	Soluble T-cell receptor	HLA-A2		Inquiry
TCR-L129	CD20	Human	A94	Human	~8kb	Lentiviral	SLFLGILSV	Soluble T-cell receptor	HLA-A2		Inquiry

CAR Viral Particles Product list:

Catalog	Antibody Clone	Packaging System	Generation	Gene Construct	Promotor	Packaging Cell	Titer	Data sheet	Price
VP-CAR-LC341	1F5	Lentivirus	First	scFv (1F5)-CD28	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC342	1F5	Lentivirus	First	scFv (1F5)-FcεRIγ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC343	1F5	Lentivirus	First	scFv (1F5)-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC344	1F5	Lentivirus	Second	scFv (1F5)-CD28-FcεRIγ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC345	1F5	Lentivirus	Second	scFv (1F5)-CD28-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC346	1F5	Lentivirus	Second	scFv (1F5)-CD4-FcεRIγ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC347	1F5	Lentivirus	Second	scFv (1F5)-CD4-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC348	1F5	Lentivirus	Second	scFv (1F5)-CD8-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC349	1F5	Lentivirus	Second	scFv (1F5)-41BB-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC350	1F5	Lentivirus	Second	scFv (1F5)-b2c-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC351	1F5	Lentivirus	Third	scFv (1F5)-CD28-41BB-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC352	1F5	Lentivirus	Third	scFv (1F5)-CD28-OX40-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC746	Leu-16	Lentivirus	First	scFv (Leu-16)-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC747	Leu-16	Lentivirus	Second	scFv (Leu-16)-CD28-41BB-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC769	Ofatumumab	Lentivirus	First	scFv (Ofatumumab)-FcγRIII	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC770	Ofatumumab	Lentivirus	First	scFv (Ofatumumab)-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC771	Ofatumumab	Lentivirus	Second	scFv (Ofatumumab)-CD28-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC772	Ofatumumab	Lentivirus	Second	scFv (Ofatumumab)-41BB-CD3ζ	CMV	293T	> 10⁷ IFU/ml		Inquiry

TCR Viral Particles Product list:

Catalog	Target Species	Antibody Clone	scFv-Host Animal	Packaging System	Epitope	Format	Titer	Data sheet	Price
VP-TCR-C311	Human	A64	Human	Lentivirus	SLFLGILSV	Soluble T-cell receptor	> 10⁷ IFU/ml		Inquiry
VP-TCR-C312	Human	A94	Human	Lentivirus	SLFLGILSV	Soluble T-cell receptor	> 10⁷ IFU/ml		Inquiry

CONTACT US

Distributors

FOLLOW US ON