CD5(Cluster of Differentiation 5), also known as Leu-1 in humans and Lyt-1 in mice, is a 67-kDa type I transmembrane glycoprotein that belongs to the highly conserved scavenger-receptor cysteine-rich superfamily. CD5 is an important physiological regulator of T-cell immune responses. The regulation of CD5 corresponds to a key event in the maintenance of immune homeostasis and tolerance. Studies based on experimental mouse models indicates that CD5 plays a key role in generation and maintenance of immune tolerance and that alterations of its activity can promote autoreactivity. CD5 is a good immunohistochemical marker for T-cells, About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies).
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