BCMA

B Cell Maturation Antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17),is encoded by TNFRSF17 gene in human. It is a transmembrane signaling protein preferentially expressed on plasma cells. It is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). Its ligands including BAFF and A Proliferation Inducing Ligand (APRIL). BCMA is involved in JNK and NF-kB activation pathways that induce B-cell development and autoimmune responses. BCMA has been implicated in autoimmune disorders as well as B-lymphocyte malignancies, leukemia, lymphomas, and multiple myeloma.

Associated Disease
  • T cell lymphoma
  • Multiple myeloma
  • Acute myelomonocytic leukemia (AMML)
  • Acute monocytic leukemia
  • Follicular lymphoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC002 T cell Second J6M0 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC041 T cell Second C12A3.2 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC042 T cell Second C11D5.3 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC043 T cell Second C11D5.3 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC044 T cell Second C11D5.3 ~8kb Lentiviral scFv-OX40-CD3ζ Mouse Inquiry
CAR-LC045 T cell Third C11D5.3 ~8kb Lentiviral scFv-41BB-OX40-CD3ζ Mouse Inquiry
CAR-LC135 T cell Second P5A2 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC136 T cell Second A02_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC137 T cell Second P5C1 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC138 T cell Second C01_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC139 T cell Second COMBO_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC140 T cell Second L3PY/H2DY ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC141 T cell Second P6AP-V1 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC260 T cell Second C12A3.2 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC261 T cell Second BC50 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC262 T cell Second BC30 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC285 T cell Third ~8kb Retroviral dAPRIL-CD28-OX40-CD3ζ Human Inquiry
CAR-LC286 T cell Third ~8kb Retroviral dAPRIL-CD8STK-CD28-OX40-CD3ζ Human Inquiry
CAR-MZ014 T cell Second C13F12.1 ~8kb Lentiviral scFv-41BB-CD3ζ Humanized Inquiry
CAR-MZ122 T cell Second 11D5-3 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-1-L335-2 T cell First MM0108-3D44 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L335-G T cell First MM0108-3D44 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L335-Z T cell First MM0108-3D44 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L335-2G T cell Second MM0108-3D44 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L335-2Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L335-4G T cell Second MM0108-3D44 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L335-4Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L335-8Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L335-BZ T cell Second MM0108-3D44 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L335-CZ T cell Second MM0108-3D44 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L335-2BZ T cell Third MM0108-3D44 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L335-2XZ T cell Third MM0108-3D44 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC25 MM0108-3D44 Lentivirus First scFv (MM0108-3D44)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC26 MM0108-3D44 Lentivirus First scFv (MM0108-3D44)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC27 MM0108-3D44 Lentivirus First scFv (MM0108-3D44)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC28 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC29 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC30 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC31 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC32 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC33 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC34 MM0108-3D44 Lentivirus Second scFv (MM0108-3D44)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC35 MM0108-3D44 Lentivirus Third scFv (MM0108-3D44)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC36 MM0108-3D44 Lentivirus Third scFv (MM0108-3D44)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC510 Lentivirus Second scFv-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC533 C12A3.2 Lentivirus Second scFv (C12A3.2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC534 C11D5.3 Lentivirus Second scFv (C11D5.3)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC535 C11D5.3 Lentivirus Second scFv (C11D5.3)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC536 C11D5.3 Lentivirus Second scFv (C11D5.3)-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC537 C11D5.3 Lentivirus Third scFv (C11D5.3)-41BB-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC619 P5A2 Lentivirus Second scFv (P5A2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC620 A02_Rd4 Lentivirus Second scFv (A02_Rd4)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC621 P5C1 Lentivirus Second scFv (P5C1)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC622 C01_Rd4 Lentivirus Second scFv (C01_Rd4)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC623 COMBO_Rd4 Lentivirus Second scFv (COMBO_Rd4)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC624 L3PY/H2DY Lentivirus Second scFv (L3PY/H2DY)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC625 P6AP-V1 Lentivirus Second scFv (P6AP-V1)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC730 C12A3.2 Lentivirus Second scFv (C12A3.2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC731 BC50 Lentivirus Second scFv (BC50)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC732 BC30 Lentivirus Second scFv (BC30)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC745 C13F12.1 Lentivirus Second scFv (C13F12.1)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC821 11D5-3 Lentivirus Second scFv (11D5-3)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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