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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MOREWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MOREUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.
EXPLORE MOREB Cell Maturation Antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17),is encoded by TNFRSF17 gene in human. It is a transmembrane signaling protein preferentially expressed on plasma cells. It is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). Its ligands including BAFF and A Proliferation Inducing Ligand (APRIL). BCMA is involved in JNK and NF-kB activation pathways that induce B-cell development and autoimmune responses. BCMA has been implicated in autoimmune disorders as well as B-lymphocyte malignancies, leukemia, lymphomas, and multiple myeloma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | Inquiry & Datasheet |
| CAR-T-1-L335-2 | Anti-BCMA scFv h(CD28) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28 | Lentiviral | T cell | |
| CAR-T-1-L335-G | Anti-BCMA scFv h(FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-FcεRIγ | Lentiviral | T cell | |
| CAR-T-1-L335-Z | Anti-BCMA scFv h(CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-L335-2G | Anti-BCMA scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-L335-2Z | Anti-BCMA scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-L335-4G | Anti-BCMA scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD4-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-L335-4Z | Anti-BCMA scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD4-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-L335-8Z | Anti-BCMA scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD8-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-L335-BZ | Anti-BCMA scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-L335-CZ | Anti-BCMA scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-b2c-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-L335-2BZ | Anti-BCMA scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-L335-2XZ | Anti-BCMA scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | MM0108-3D44 | Rat | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | |
| CAR-LC002 | Anti-BCMA (J6M0)h(41BB-CD3ζ) CAR, pCDCAR1 | Human | J6M0 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC135 | Anti-BCMA (P5A2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | P5A2 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC136 | Anti-BCMA (A02_Rd4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | A02_Rd4 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC137 | Anti-BCMA (P5C1) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | P5C1 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC138 | Anti-BCMA (C01_Rd4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | C01_Rd4 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC139 | Anti-BCMA (COMBO_Rd4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | COMBO_Rd4 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC140 | Anti-BCMA (L3PY/H2DY) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | L3PY/H2DY | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC141 | Anti-BCMA (P6AP-V1) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | P6AP-V1 | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC260 | Anti-BCMA (C12A3.2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | C12A3.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC261 | Anti-BCMA (BC50) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BC50 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC262 | Anti-BCMA (BC30) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BC30 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-LC285 | Anti-TNFRSF17 h(CD28-OX40-CD3ζ) Ligand-based CAR, pCDCAR1 | Human | Human | dAPRIL-CD28-OX40-CD3ζ | Retroviral | T cell | ||
| CAR-LC286 | Anti-TNFRSF17 h(CD8STK-CD28-OX40-CD3ζ) Ligand-based CAR, pCDCAR1 | Human | Human | dAPRIL-CD8STK-CD28-OX40-CD3ζ | Retroviral | T cell | ||
| CAR-MZ014 | Anti-BCMA (C13F12.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | C13F12.1 | Humanized | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-MZ122 | Anti-BCMA (11D5-3) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 11D5-3 | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-YF131 | Anti-BCMA (7G2) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 7G2 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF132 | Anti-BCMA (7G2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 7G2 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF133 | Anti-BCMA (7A12) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 7A12 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF134 | Anti-BCMA (7A12) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 7A12 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF135 | Anti-BCMA (23F10) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 23F10 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF136 | Anti-BCMA (23F10) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 23F10 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF175 | Anti-BCMA (CBL-YF057) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF057 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF220 | Anti-BCMA (BCMA-50) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | BCMA-50 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF221 | Anti-BCMA (BCMA-50) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | BCMA-50 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF222 | Anti-BCMA (BCMA-30) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | BCMA-30 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF223 | Anti-BCMA (BCMA-30) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | BCMA-30 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF224 | Anti-BCMA (C13F12.1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | C13F12.1 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell |
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