Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states. Tumoral PD-L1 expression status has been shown to be prognostic in multiple tumor types, including melanoma (MEL), renal cell carcinoma (RCC), and non–small-cell lung cancer (NSCLC).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC282 | Anti-CD274 h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 | Human | PD1-41BB-CD3ζ | Retroviral | T cell | ||||
| CAR-YF074 | Anti-PD-L1 (CBL-YF021) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF021 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF075 | Anti-PD-L1 (CBL-YF021) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF021 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF098 | Anti-PD-L1 (CBL-YF032) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF032 | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF099 | Anti-PD-L1 (CBL-YF032) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF032 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF129 | Anti-PD-L1 (CBL-YF044) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF044 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF130 | Anti-PD-L1 (CBL-YF044) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF044 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF155 | Anti-PD-L1 (CBL-YF048) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF048 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YF156 | Anti-PD-L1 (CBL-YF048) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL-YF048 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP108 | Anti-PD-L1 h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 0 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP109 | Anti-PD-L1 h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 0 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP258 | Anti-PD-L1 (MEDI4736) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | MEDI4736 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP259 | Anti-PD-L1 (MEDI4736) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | MEDI4736 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP260 | Anti-PD-L1 (RG7446) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | RG7446 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP261 | Anti-PD-L1 (RG7446) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | RG7446 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP264 | Anti-PD-L1 (3G10) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 3G10 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP265 | Anti-PD-L1 (3G10) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 3G10 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP266 | Anti-PD-L1 (10A5) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 10A5 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP267 | Anti-PD-L1 (10A5) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 10A5 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP268 | Anti-PD-L1 (5F8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 5F8 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0823-LX83 | Anti-hPD-L1 (736) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 736 | Adenoviral vectors |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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