CD138,or more well know as syndecan-1,encoded by SDC1 gene in human, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. Expression of syndecan-1 typically is observed on the surface of mature epithelial cells; however, stromal expression also might be seen in developing tissues. It is also found on distinct stages of differentiation of normal lymphoid cells (pre-B), mesenchymal cells during development and in mature plasma cells. In addition to plasma cells, CD138 reactivity also has been described for the plasmacytoid tumor cells of herpesvirusassociated effusion lymphomas and has been reported with variable frequency in immunoblastic diffuse large B cell lymphoma (DLBCL). It is also a specific antigen on multiple myeloma cells. Indatuximab ravtansine targets this protein.
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