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CD138

CD138,or more well know as syndecan-1,encoded by SDC1 gene in human, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. Expression of syndecan-1 typically is observed on the surface of mature epithelial cells; however, stromal expression also might be seen in developing tissues. It is also found on distinct stages of differentiation of normal lymphoid cells (pre-B), mesenchymal cells during development and in mature plasma cells. In addition to plasma cells, CD138 reactivity also has been described for the plasmacytoid tumor cells of herpesvirusassociated effusion lymphomas and has been reported with variable frequency in immunoblastic diffuse large B cell lymphoma (DLBCL). It is also a specific antigen on multiple myeloma cells. Indatuximab ravtansine targets this protein.

Associated Disease
  • Multiple Myelomas
  • Haematological malignancies
  • Diffuse large B cell lymphoma (DLBCL)
  • CAR Vector Products
  • CAR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type  
CAR-LC170 Anti-CD138 (Indatuximab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Indatuximab Human scFv-CD28-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-LC384 Anti-CD138 (NI16) h(CD28-CD3ζ,iCasp-9) Self-destruct CAR, pCDCAR1 Human NI16 Mouse scFv-CD28-41BB-CD27-CD3ζ/iCasp9 Lentiviral T cell   Inquiry
  Datasheet
CAR-MZ104 Anti-CD138 (Indatuximab) scFv h(41BB-CD3ζ) CAR, pCDCAR1 Human Indatuximab Human scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet

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