LeY

LeY represents lewis antigen. The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional. There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). They are red cell antigens which are not produced by the erythrocyte itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the erythrocyte. The Le(b) and H antigens are receptors for the bacteria Helicobacter pylori, a gram-negative bacterium that can cause gastritis and has been implicated in peptic ulcer disease, gastric adenocarcinoma, mucosa-associated lymphoma (or mucosal associated lymphatic tissue lymphoma- MALToma) and idiopathic thrombocytopenic purpura (ITP).

Associated Disease
  • LeY-expressing acute myeloid leukemia (AML)
  • Acute myeloid leukemia (AML)

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-M320-2 T cell First 3S193 8kb Lentiviral scFv-CD28 Humanized Inquiry
CAR-T-1-M320-G T cell First 3S193 8kb Lentiviral scFv-FcεRIγ Humanized Inquiry
CAR-T-1-M320-Z T cell First 3S193 8kb Lentiviral scFv-CD3ζ Humanized Inquiry
CAR-T-2-M320-2G T cell Second 3S193 8kb Lentiviral scFv-CD28-FcεRIγ Humanized Inquiry
CAR-T-2-M320-2Z T cell Second 3S193 8kb Lentiviral scFv-CD28-CD3ζ Humanized Inquiry
CAR-T-2-M320-4G T cell Second 3S193 8kb Lentiviral scFv-CD4-FcεRIγ Humanized Inquiry
CAR-T-2-M320-4Z T cell Second 3S193 8kb Lentiviral scFv-CD4-CD3ζ Humanized Inquiry
CAR-T-2-M320-8Z T cell Second 3S193 8kb Lentiviral scFv-CD8-CD3ζ Humanized Inquiry
CAR-T-2-M320-BZ T cell Second 3S193 8kb Lentiviral scFv-41BB-CD3ζ Humanized Inquiry
CAR-T-2-M320-CZ T cell Second 3S193 8kb Lentiviral scFv-b2c-CD3ζ Humanized Inquiry
CAR-T-3-M320-2BZ T cell Third 3S193 8kb Lentiviral scFv-CD28-41BB-CD3ζ Humanized Inquiry
CAR-T-3-M320-2XZ T cell Third 3S193 8kb Lentiviral scFv-CD28-OX40-CD3ζ Humanized Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC317 3S193 Lentivirus First scFv (3S193)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC318 3S193 Lentivirus First scFv (3S193)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC319 3S193 Lentivirus First scFv (3S193)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC320 3S193 Lentivirus Second scFv (3S193)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC321 3S193 Lentivirus Second scFv (3S193)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC322 3S193 Lentivirus Second scFv (3S193)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC323 3S193 Lentivirus Second scFv (3S193)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC324 3S193 Lentivirus Second scFv (3S193)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC325 3S193 Lentivirus Second scFv (3S193)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC326 3S193 Lentivirus Second scFv (3S193)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC327 3S193 Lentivirus Third scFv (3S193)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC328 3S193 Lentivirus Third scFv (3S193)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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