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LeY

LeY represents lewis antigen. The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional. There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). They are red cell antigens which are not produced by the erythrocyte itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the erythrocyte. The Le(b) and H antigens are receptors for the bacteria Helicobacter pylori, a gram-negative bacterium that can cause gastritis and has been implicated in peptic ulcer disease, gastric adenocarcinoma, mucosa-associated lymphoma (or mucosal associated lymphatic tissue lymphoma- MALToma) and idiopathic thrombocytopenic purpura (ITP).

Associated Disease
  • LeY-expressing acute myeloid leukemia (AML)
  • Acute myeloid leukemia (AML)
  • CAR Vector Products
  • CAR Viral Particles
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  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-M320-2 Anti-LeY scFv h(CD28) CART, pCDCAR1 Human 3S193 Humanized scFv-CD28 Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-M320-G Anti-LeY scFv h(FcεRIγ) CART, pCDCAR1 Human 3S193 Humanized scFv-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-M320-Z Anti-LeY scFv h(CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-2G Anti-LeY scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD28-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-2Z Anti-LeY scFv h(CD28-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-4G Anti-LeY scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD4-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-4Z Anti-LeY scFv h(CD4-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD4-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-8Z Anti-LeY scFv h(CD8-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD8-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-BZ Anti-LeY scFv h(41BB-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M320-CZ Anti-LeY scFv h(b2c-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-b2c-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-M320-2BZ Anti-LeY scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-M320-2XZ Anti-LeY scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human 3S193 Humanized scFv-CD28-OX40-CD3ζ Lentiviral T cell   Inquiry
  Datasheet

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