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CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell. Using its intracellular domain, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 continues to be expressed in most neoplasms derived from T helper cells. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-0622-ZP3175 | Anti-CD4 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3347 | Anti-CD4 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0722-YF25 | TS-Fluc Anti-Human CD4 scFv (Ibalizumab) CD28-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF85 | TS-Fluc Anti-Human CD4 scFv (Ibalizumab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF145 | TS-Fluc Anti-Human CD4 scFv (Ibalizumab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF205 | TS-IL15 SA Anti-Human CD4 scFv (Ibalizumab) CD28-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-IL15 SA-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF265 | TS-IL15 SA Anti-Human CD4 scFv (Ibalizumab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF325 | TS-IL15 SA Anti-Human CD4 scFv (Ibalizumab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF385 | TS-NKG2DL Anti-hCD3 and Anti-Human CD4 scFv (Ibalizumab) CD28-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF445 | TS-NKG2DL Anti-hCD3 and Anti-Human CD4 scFv (Ibalizumab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF505 | TS-NKG2DL Anti-hCD3 and Anti-Human CD4 scFv (Ibalizumab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Ibalizumab | Mouse | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0822-YF160 | Anti-Human CD4 (XW-160) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-160 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF161 | Anti-Human CD4 (XW-161) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-161 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF162 | Anti-Human CD4 (XW-162) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-162 | Humanized | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF163 | Anti-Human CD4 (XW-163) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-163 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF164 | Anti-Human CD4 (XW-164) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-164 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF165 | Anti-Human CD4 (XW-165) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-165 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF166 | Anti-Human CD4 (XW-166) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-166 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF167 | Anti-Human CD4 (XW-167) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-167 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF168 | Anti-Human CD4 (XW-168) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-168 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0823-LX19 | Anti-hCD4 (17b) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 17b | Adenoviral vectors |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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