Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell. Using its intracellular domain, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 continues to be expressed in most neoplasms derived from T helper cells. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-0120ZP3123 | Anti-CD4 (Priliximab) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Priliximab | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3124 | Anti-CD4 (Priliximab) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | Priliximab | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3143 | Anti-CD4 (TRX1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | TRX1 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3144 | Anti-CD4 (TRX1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | TRX1 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3145 | Anti-CD4 (M-T412) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | M-T412 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3146 | Anti-CD4 (M-T412) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | M-T412 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3147 | Anti-CD4 (OKT4A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | OKT4A | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3181 | Anti-CD4 (MIL17) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | MIL17 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3182 | Anti-CD4 (MIL17) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | MIL17 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3183 | Anti-CD4 (YTS177.9) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | YTS177.9 | Rat | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3184 | Anti-CD4 (YTS177.9) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | YTS177.9 | Rat | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3185 | Anti-CD4 (B486) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | B486 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3186 | Anti-CD4 (B486) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | B486 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3187 | Anti-CD4 (HIT4a) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | HIT4a | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3292 | Anti-CD4 (2D1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 2D1 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3295 | Anti-CD4 (247109) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 247109 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3296 | Anti-CD4 (247109) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 247109 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3299 | Anti-CD4 (1D6) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 1D6 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3300 | Anti-CD4 (1D6) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 1D6 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP3303 | Anti-CD4 (1D1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 1D1 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| XS-0823-LX19 | Anti-hCD4 (17b) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 17b | Adenoviral vectors |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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