CD4

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CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell. Using its intracellular domain, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 continues to be expressed in most neoplasms derived from T helper cells. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma.

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  • Non-Hodgkin's lymphomas
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-0120ZP3287 Anti-CD4 (2H8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2H8 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP3288 Anti-CD4 (2H8) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2H8 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP3291 Anti-CD4 (2D1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D1 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-SB-LX0122 Anti-CD4 (TRX1) h(CD28-CD3ζ) CAR, pSBCAR1 Human TRX1 Humanized scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
CAR-SB-LX0123 Anti-CD4 (M-T412) h(CD28-CD3ζ) CAR, pSBCAR1 Human M-T412 Mouse scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
CAR-SB-LX0124 Anti-CD4 (OKT4A) h(CD28-CD3ζ) CAR, pSBCAR1 Human OKT4A Mouse scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
CAR-SB-LX0127 Anti-CD4 (Clenoliximab) h(CD28-CD3ζ) CAR, pSBCAR1 Human Clenoliximab Mouse scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0322-LX138 Anti-CD4 (17b) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human 17b Human scFv-CD28-OX40-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0322-LX139 Anti-CD4 (KM8045) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human KM8045 humanized scFv-CD28-OX40-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0322-LX140 Anti-CD4 (KM4045) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human KM4045 humanized scFv-CD28-OX40-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0322-LX144 Anti-CD4 (VH3/VK2) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human VH3/VK2 Mouse scFv-CD28-OX40-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0322-LX145 Anti-CD4 (5A8) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human 5A8 Mouse scFv-CD28-OX40-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0322-LX627 Anti-CD4 (KM4065) h(4-1BB-CD3ζ) CAR, pSBCAR1 Human KM4065 Rat scFv-4-1BB-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0322-LX628 Anti-CD4 (B-F5) h(4-1BB-CD3ζ) CAR, pSBCAR1 Human B-F5 Mouse scFv-4-1BB-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0322-LX629 Anti-CD4 (VH2/VK1) h(4-1BB-CD3ζ) CAR, pSBCAR1 Human VH2/VK1 Mouse scFv-4-1BB-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0322-LX630 Anti-CD4 (VH3/VK2) h(4-1BB-CD3ζ) CAR, pSBCAR1 Human VH3/VK2 Mouse scFv-4-1BB-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0823-LX19 Anti-hCD4 (17b) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector Human 17b Adenoviral vectors   Add to Cart   Datasheet
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