CD70

CD70 (Cluster of Differentiation 70) is a ligand for CD27, CD70 binds to its unique receptor, CD27, a TNFR superfamily type I transmembrane glycoprotein. Expression of CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T and B lymphocytes and mature dendritic cells. CD70 has also been detected on hematological tumors and on carcinomas. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC293 T cell First ~8kb Retroviral CD27-CD3ζ Human Inquiry
CAR-LC347 T cell First ~8kb Retroviral CD27-CD3ζ-CD19t Mouse Inquiry
CAR-T-1-L405-2 T cell First 8kb Lentiviral scFv-CD28 Human Inquiry
CAR-T-1-L405-G T cell First 8kb Lentiviral scFv-FcεRIγ Human Inquiry
CAR-T-1-L405-Z T cell First 8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-T-2-L405-2G T cell Second 8kb Lentiviral scFv-CD28-FcεRIγ Human Inquiry
CAR-T-2-L405-2Z T cell Second 8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-T-2-L405-4G T cell Second 8kb Lentiviral scFv-CD4-FcεRIγ Human Inquiry
CAR-T-2-L405-4Z T cell Second 8kb Lentiviral scFv-CD4-CD3ζ Human Inquiry
CAR-T-2-L405-8Z T cell Second 8kb Lentiviral scFv-CD8-CD3ζ Human Inquiry
CAR-T-2-L405-BZ T cell Second 8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-T-2-L405-CZ T cell Second 8kb Lentiviral scFv-b2c-CD3ζ Human Inquiry
CAR-T-3-L405-2BZ T cell Third 8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-T-3-L405-2XZ T cell Third 8kb Lentiviral scFv-CD28-OX40-CD3ζ Human Inquiry
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Tel: 1-631-871-5806
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Email:

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Tel: 44-207-097-1828

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