Archaeosomes

Archaeosomes have been recognized as tremendously useful carrier systems and helpful in the delivery of various cargoes to the target sites. With the cumulative amount of clinical trials involving archaeosomes and lipid-based products, Creative Biolabs is aggressively affianced in the development and evaluation of archaeosomes products. At present, scientists at Creative Biolabs offer our clients high-quality services for archaeosomes preparation and supply commercial archaeosomes products according to their demands.

Archaeosomes

Archaeosomes are liposomal formulations that are prepared with one or more lipids, mainly containing diether and/or tetraether linkages, found in archaeobacterial membrane. These archaeobacterial lipids present unique features and higher stabilities to several conditions including high or low temperatures, high salinity, acidic media, anaerobic atmosphere, high pressure over conventional liposomes. The surprising stability of archaeosomes can be attributed to the following properties brought by the archaeobacterial lipids’ structure:

1. The ether linkages are more stable than esters over a wide range of pH.
2. The branching methyl groups help to reduce both crystallization and permeability.
3. The unusual stereochemistry of the glycerol backbone ensures the resistance of the membrane to enzymatic attack.
4. The bipolar lipids span the membranes and enhance their stability properties.

The biocompatibility and better stability of archaeosomes in numerous conditions offer advantages over conventional liposomes for their usage in biotechnology including vaccine and drug/gene delivery. Thus, archaeosomes can be considered as better carriers especially for protein and peptide delivery due to their high stability.

Fig.1 Structure of archaeosomes.

Applications of Archaeosomes

Archaeosomes induce strong CD4⁺ as well as CD8⁺ CTL responses to entrapped soluble antigens and thus have been used in self-adjuvanting drug delivery systems for cancer vaccines. Additionally, archaeosomes have also been widely used in other aspects of drug delivery. Since archaeosomes are a type of liposomes prepared from the polar lipids of various archaeobacteria, they may be used to deliver different types of cargoes such as gene, small fluorescent molecules, peptides, small proteins, large protein aggregates and natural antioxidant compounds into epithelial cells.

Fig.2 Thermosensitive archeasomes offer stability and controlled drug release¹.

What We Can Do about Archaeosomes?

Aided by our well-established platforms and experienced scientists, we can provide comprehensive archaeosomes services, varying from lipid-based drug delivery characterization, delivery system construction services to in vitro efficacy validation, in vivo PK/PD validation. A wide spectrum of customized delivery products is available for your choice.

Drug delivery by vesicular system has overtaken the pre-existing drugs by improving therapeutic efficacy and by sustaining and controlling action. If you are interested in our archaeosomes system and related services, please free to contact us for more information. Creative Biolabs will help you make great progress.

For Research Use Only. Not For Clinical Use