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Lipid-based Delivery System Development Formulation Analysis and Characterization Pharmacodynamic Study

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Custom Lipid Synthesis Service

Lipids are chemically a kind of biomolecule that is soluble in nonpolar solvents. They are important components of living cells and play vital roles in energy storage, signaling, and cell membrane formation. And thus, lipids are now widely used in cosmetic and food industries, as well as in nanotechnology-based therapeutics. Some amphiphilic lipids can form structures such as vesicles, micelles, nanotubes, and multilamellar/unilamellar liposomes, which are excellent carriers for nutrients and therapeutic agents.

As one of the leading companies in the field of lipid-based drug delivery, Creative Biolabs has extensive experience in lipid design and synthesis. Our expert team is always ready to solve any synthetic problems and provide the highest quality products for the smooth conduction of your research.

Fig.1 Custom lipid synthesis. (Creative Biolabs Original)Fig 1. Custom lipid synthesis. (Creative Biolabs)

Custom Synthesis

Common lipids used to form nanocarriers are amphiphilic molecules with a hydrophilic head group and hydrophobic fatty acid tails. For example, phospholipids are widely used for the preparation of liposomes. If you cannot find an ideal lipid in our product catalog or need lipid with specific functions, contact us directly for a one-to-one lipid development service. Our featured services for custom lipid synthesis include:

Head group modification

Fatty acid chains modification

  • Phase-transition lipids
  • Diphytanoyl lipids
  • Biotinylated lipids
  • Halogenated lipids
  • Oxidized lipids

Besides, Creative Biolabs is able to design and synthesize other macro amphiphilic molecules through conjugation, which can also form micelle structures and act as controlled release drug carriers. The molecules may include amphipathic polymers, polymer-peptide conjugate, polymer-lipid conjugate, drug-lipid conjugate, etc.

Lipid Purification & Analysis Tools

To ensure the quality of the synthetic lipids, we have also established a set of systematic analysis methods based on the LipoDrive™ lipid research platform. The available analytical tools include:

  • Thin-layer chromatography (TLC)
  • High-performance liquid chromatography (HPLC)
  • Nuclear magnetic resonance (NMR)
  • Gas chromatography-mass spectrometry (GC-MS)
  • Liquid chromatography-mass spectrometry (LC-MS)
  • Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS)

For more information about our service, please feel free to contact us and do extraordinary work together.

For Research Use Only. Not For Clinical Use