Pro-niosomes

Pro-vesicular approach has been proposed to enhance the stability of vesicles. Pro-niosomes is a compact semi-solid liquid crystalline product of non-ionic surfactant easily formed on dissolving the surfactant in minimal amount of acceptable solvent and the least amount of aqueous phase. As the first-in-class biotech developer and provider, scientists of Creative Biolabs focus on applying outstanding technologies to the discovery and development of potential drug delivery approaches, such as custom lipid-based drug delivery (LDD) services. Based on advanced technology and years of research, we are confident to provide high-quality custom services and products which can greatly assist your drug delivery project.

Background of Pro-niosomes

Niosomes are nonionic surfactant vesicles that have potential applications in the delivery of hydrophobic and hydrophilic drugs. From a technical point of view, niosomes are promising drug carriers as they possess greater chemical stability and lack of many disadvantages associated with liposomes, such as high-cost and variable purity problems of phospholipids. Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier, pro-niosomes (PNs). They are microscopic lamellar structures which combine a non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol followed by hydration in aqueous media. The surfactant molecules direct themselves such that the hydrophilic ends of the non-ionic surfactant orient outward, while the hydrophobic ends are in the opposite direction to form the bilayer. Like liposomes, PNs are also made up of a bilayer. In PNs, the bilayer is made of non-ionic surface active agents. On the basis of method of preparation PNs are unilamellar or multi-lamellar. The niosome is made of a surfactant bilayer with its hydrophilic ends exposed on the outside and inside of the vesicles while the hydrophobic chains face each other within the bilayer. Hence the vesicle holds hydrophilic drugs within the space enclosed in the vesicle and the hydrophobic drugs are embedded within the bilayer.

Fig.1 Niosomes formation from PNs by hydration.

Pro-niosomes in Drug Delivery

PNs have gained wide attention for their use as drug targeting agents and drug carriers to have a variety of merits while avoiding demerits associated with the conventional form of drugs. They are rehydrated to form niosomal dispersion immediately before use on agitation in hot aqueous media within minutes. The resulting niosomes are very correlative to conventional niosomes and of higher size uniformity. Moreover, PNs help in reducing physical stability problems involved with niosomes such as leaking, fusion, aggregation and provide convenience in dosing, distribution, transportation and storage showing improved results than conventional niosomes. The additional merits with PNs are low toxicity owing to non-ionicnature, no requirement of special precautions and conditions for formulation and preparations. In addition, it is the simple method for the routine and large scale production of proniosomes without the use of undesirable solvents. Drug encapsulated in the vesicular structure of PNs prolong the existence of drug in the systematic circulation and enhances the penetration into target tissue and reduce toxicity. Therefore, PNs were studied as alternatives to liposomes and other carrier systems for entrapping both polar and nonpolar or hydrophobic and hydrophilic drugs.

What We Can Do about Pro-niosomes?

In vivo behavior of PN derived niosomes will be similar to liposomes showing advantages as drug carriers, comprising lower cost and toxicity. Encapsulation of drug in PNs reduces the toxicity in various therapies and applications and also prolongs the encapsulated drug circulation time and changes drug distribution in the body. Aided by our well-established platforms and experienced scientists, a wide spectrum of PNs products is available for your choice. Furthermore, we can provide customized services of LDD formulation for drug delivery.

• Custom platform
• Planning and design
• Seasoned technology
• One-stop pipeline
• High efficiency
• Best after-sale service

Based on proven and optimized platforms, Creative Biolabs offers high-quality custom services and products covering the entire LDD development process to best suit your technical, program and budget requirements which can greatly assist your research. Please contact us for more information.

For Research Use Only. Not For Clinical Use