Liposome Delivery System Development Services

Liposomes have received attention not only because of their use as a model membrane system, but also for drug delivery. As a drug delivery system, liposomes have significant therapeutic advantages in the targeting and controlled release of active ingredients.

Introduction of Liposomal Formulation

Liposomes are an ideal drug delivery system because they are similar in morphology to cell membranes and can incorporate various substances. Therefore, liposomes have been widely studied in recent 50 years, and continue to be the hotspot of research. As the optimal drug delivery system for biologically active substances both in vitro and in vivo, liposomes have attracted much attention due to their biological and technological advantages, and are considered to be the most successful drug delivery system so far. Liposomal formulations can be used to overcome the non-ideal properties of drugs, such as limited solubility, serum stability, circulation half-life, biodistribution and target tissue selectivity.

Fig.1 Different drugs for liposomal delivery

Liposomal Formulation Development Service

Liposome is a recognized pharmaceutical formulation technology, which can be administered locally, orally, or through the lung or parenteral route. Since we have mastered a series of liposome preparation methods, Creative Biolabs, together with our experienced scientific team, is confident to produce a variety of high-quality liposomes to meet the delivery of different drugs.

• Liposome Encapsulated Small Molecule Drugs

Small molecule therapies infused in vivo can cause uncontrolled bio-distribution, leading to dilution and undesirable side effects. Liposomes can encapsulate hydrophilic and lipophilic small molecule therapeutics, protect them from physiological degradation and deliver them to target cells.

• Liposome Encapsulated Protein/Peptide

Therapeutic proteins play a fundamental role in the treatment of many diseases. The low physicochemical stability of protein under physiological conditions threatens its function in human body until it reaches its goal. The use of liposome delivery system provides solutions to these limitations and improves the therapeutic effect of protein-based drug delivery.

• Liposome Encapsulated Prodrug

Nano-drug delivery systems and prodrug strategies have been used in efficient cancer chemotherapy regimens. Liposomes are used to encapsulate prodrugs and deliver them to the disease site to ensure their safety and drug activity.

• Liposome Encapsulated Nucleic Acids

Liposomes as carriers of nucleic acids, either as plasmid vectors for gene therapy, or delivery of smaller nucleic acid species, such as antisense oligonucleotides, ribozymes and siRNAs, have attracted considerable interest in targeting genes.

• Liposome-Based Adjuvant

Also, liposome is an effective vaccine antigen carrier, which can form a multifunctional vaccine adjuvant delivery system. When the liposome is modified by a lipoidal immune enhancer and other special functional molecules, it can effectively realize the dual functions of adjuvant and delivery.

What We Can Do about Liposomal Formulation Development?

• Various types of liposome-based drug delivery systems
• Controlled/sustained release drug delivery system
• Pre-formulation, formulation feasibility and prototype development
• A variety of mature preparation technologies are available
• Various identification and standardization methods
• Process optimization (experimental design) and aseptic filtration

For more details about our liposomal formulation development services, please feel free to contact us.

For Research Use Only. Not For Clinical Use