Online Inquiry

Liposomal Formulation Development Service

Services Applications Advantages Backgroud Technology Related Services FAQs Resources

Liposomal formulations are vital in overcoming limitations associated with drug bioavailability and site-specific activity. Creative Biolabs specializes in comprehensive liposomal formulation development services, offering robust solutions tailored to diverse research and pharmaceutical applications.

Liposomal Formulation Development Services

Since we have mastered a series of liposome preparation methods, Creative Biolabs, together with our experienced scientific team, is confident to produce a variety of high-quality liposomes to meet the delivery of different drugs.

Services	Description
Liposome Encapsulated Small Molecule Drugs	Liposomes can encapsulate hydrophilic and lipophilic small molecule therapeutics, protecting them from physiological degradation and delivering them to target cells. This approach addresses uncontrolled bio-distribution, dilution, and undesirable side effects commonly associated with small molecule therapies infused in vivo.
Liposome Encapsulated Protein/Peptide	Liposomes stabilize therapeutic proteins and peptides, overcoming their low physicochemical stability under physiological conditions. This delivery system ensures the effective protection and functional preservation of protein-based drug formulations until they reach their targets.
Liposome Encapsulated Prodrug	By encapsulating prodrugs within liposomes, nano-drug delivery systems enhance the safety and activity of chemotherapy agents. Liposomes ensure that prodrugs are effectively delivered to targeted disease sites, improving therapeutic outcomes in cancer treatment.
Liposome Encapsulated Nucleic Acids	Liposomes serve as efficient carriers for nucleic acids, such as plasmid vectors for gene therapy or smaller species like antisense oligonucleotides, ribozymes, and siRNAs. These systems provide targeted gene delivery with improved stability and efficacy.
Liposome-Based Adjuvant	Liposomes act as effective vaccine antigen carriers, forming multifunctional vaccine adjuvant systems. Modified with immune enhancers and other functional molecules, liposomes achieve dual functions as both delivery vehicles and immune-boosting adjuvants.

Creative Biolabs also specializes in controlled/sustained release systems, offering tailored drug release profiles to match therapeutic needs, and custom liposome formulations, providing unique charge modifications, unilamellar or multilamellar vesicles, and other specific customizations to meet individual project requirements, contact us for more information.

Applications of Liposomal Formulation Development

Liposomal formulations are integral to numerous research domains, offering targeted and efficient delivery for challenging applications:

Applications	Description
Cancer Drug Delivery	Enhances the delivery of chemotherapeutic agents to tumor sites, minimizing off-target effects.
Gene Delivery	Facilitates the transport of siRNAs, antisense oligonucleotides, or plasmid DNA into target cells.
Vaccine Development	Utilizes liposomal adjuvants to improve antigen presentation and immune responses.
Biomolecule Stabilization	Encapsulates proteins or peptides to protect them from degradation and enhance bioavailability.
Controlled Drug Release	Ensures precise and sustained release of small molecule drugs, reducing dosing frequency and optimizing therapeutic outcomes.

Advantages of Our Liposomal Formulation Development Service

We offer unmatched advantages in liposomal formulation development:

Expertise and Innovation: Years of experience combined with proprietary techniques ensure the highest quality outcomes.
Comprehensive Customization: From encapsulation efficiency to lipid composition, all formulations are tailored to project requirements.
Cost-Effective Solutions: Optimized processes reduce both time and costs while ensuring compliance with stringent quality standards.
Seamless Scalability: Manufacturing processes are designed to scale efficiently from laboratory to production scale.
Dedicated Support: A highly experienced team provides guidance through every stage, from pre-formulation to regulatory compliance.

Background of Liposomal Formulation

Liposomes are an ideal drug delivery system because they are similar in morphology to cell membranes and can incorporate various substances. Therefore, liposomes have been widely studied in the past 50 years, and continue to be the hotspot of research. As the optimal drug delivery system for biologically active substances both in vitro and in vivo, liposomes have attracted much attention due to their biological and technological advantages, and are considered to be the most successful drug delivery system so far. Liposomal formulations can be used to overcome the non-ideal properties of drugs, such as limited solubility, serum stability, circulation half-life, biodistribution and target tissue selectivity.

Fig. 1 Different drugs for liposomal delivery. (Creative Biolabs Original) Fig.1 Different drugs for liposomal delivery

Technology and Platform Support

Creative Biolabs integrates advanced technologies to optimize liposomal formulations:

Aseptic Processing Technologies: Ensure sterility during manufacturing, critical for pharmaceutical-grade products.
Dynamic Light Scattering (DLS) and Transmission Electron Microscope (TEM): Provide detailed characterization of liposome size, morphology, and polydispersity.
High-Throughput Screening Platforms: Allow rapid optimization of lipid composition and encapsulation parameters.
Lyophilization and Stability Studies: Develop long-term stable formulations for enhanced storage and transportation.
Customizable Platforms: Tailored solutions support both unilamellar and multilamellar vesicles, depending on the application.