Stimuli-Responsive Liposome Development Service

Liposomes are a promising nanocarrier for drug delivery due to their biocompatibility and drug encapsulation ability. They can be easily functionalized by introducing functional materials (such as stimulus-responsive materials). Creative Biolabs can provide you with professional solutions for the preparation and characterization of various stimuli-responsive liposomes.

Background of Stimuli-Responsive Liposome

The ultimate goal of drug delivery is to increase the bioavailability and reduce its side effects by releasing active pharmaceutical ingredient (API) at specific sites of action. In the case of anti-tumor therapy, the combination of therapeutic agent and carrier system can minimize the damage to healthy non target tissues. At the same time, due to enhanced permeability and retention (EPR), it can limit systemic release and promote long circulation to enhance uptake of cancer site. Stimuli-responsive systems have become a promising method for delivering and releasing payloads in a site-selective manner. Specific sources of intracellular or extracellular activation by chemical, biochemical or physical means can change the structural state of liposomes, thereby promoting the release of drugs in a specific biological environment.

Fig.1 Stimuli-responsive liposomes for drug delivery

Strategies of Stimuli-Responsive Liposome Preparation

The combination of external or internal stimulation with stimuli-responsive liposomes is an effective way to improve the therapeutic effect of liposomal drug delivery system and reduce adverse reactions. The unique characteristics in the tumor microenvironment can be used as an endogenous stimulus (pH, redox potential or unique enzyme activity) or a place for applied external stimuli (heat or light) to trigger the controlled release of API. In liposome carrier systems, triggered release is usually based on the principle of membrane instability caused by local defects in the bilayer membrane to achieve the release of drugs encapsulated in liposomes. Different chemical activation methods (pH, enzymes, redox, and light) have been used to impart stimulus response characteristics to liposomes for drug delivery.

What We Can Do about Stimuli-Responsive Liposome Development?

The precise design and control of the structure of stimuli-responsive materials and the combination with functional materials are expected to create new methods to control biological functions, and to prepare highly effective liposomes which can selectively release bioactive molecules. Relying on our professional team of scientists, Creative Biolabs provides a variety of stimuli-responsive liposome preparation and characterization analysis services, including:

Temperature-responsive liposomes

pH-responsive liposomes

Enzyme-responsive liposomes

Redox-responsive liposomes

Light-responsive liposomes

Our researchers can find the best combination of formula factors through fewer experiments, and obtain liposomes with expected performance. For more details about our services, please directly contact us.

For Research Use Only. Not For Clinical Use