Lipid-Based Drug Delivery Systems in Cancers

Lipid-based drug delivery system is a newly developed drug carrier which can be applied for various cancers targeted treatment with many superiorities. Creative Biolabs can provide our global customers with first class services about lipid-based drug delivery system applied for cancer treatment.

Background of Cancer Treatment

Cancer, the second-leading cause of death throughout the world, is a group of diseases characterized by abnormal cell growth with uncontrollable division and the potential to invade or spread to other parts of the body. Cancer treatment can be commonly implemented by surgery, chemotherapy, radiation therapy, immunotherapy, hormonal therapy or a combination of these and so forth, which is determined by many factors like the type and stage of the cancer, location, size, and patient. Although these different therapies are effective for cancer treatment, there are still some limitations that need to be settled, such as:

• Surgery removing treatments are suitable to those invisible or definite cancers and resectable tumors.
• Radiation treatments using high-energy x-rays or other particles can effectively destroy cancer cells, but can also damage noncancerous cells.
• Chemotherapy is a systemic cancer treatment that destroys reproducing cells, which also can’t recognize noncancerous cells and has great toxicity and side effects like fatigue, pain, hair loss, nausea, and vomiting.
• Hormone therapy is limited to the treatments of breast or prostate cancers and other hormone receptor-positive cancers.
• Some anti-cancer agents are highly hydrophobic, resulting in low bioavailability.

Lipid-Based Drug Delivery System Applied for Cancer Treatment

To improve these complications of conventional cancer treatment, novel cancer drug delivery system emerges as the times require, which has made great improvements in cancer screening, treatment and survival. And lipid-based drug delivery system is a carrier of cytotoxic or anti-cancer drugs with safe, intelligent therapeutic effects and higher efficacy/toxicity values for tumors. Plenty of literature has demonstrated that lipid-based drug delivery systems perform well when used in cancer research and treatment as a therapeutic and diagnostic tool. The most notable properties of lipid-based drug carriers is the minimization of targeted therapies and toxic side effects. Lipid-based drug delivery system also displays many other advantages when applied for cancer treatment, including but not limited to:

• Enhanced bioavailability of hydrophobic anti-cancer drugs
• Reducing the clearance of anti-tumor drugs by immunity
• Prolonging the systemic circulation time of delivered anti-tumor drugs
• Improvement of multidrug-resistance

Fig.1 The pH-sensitive liposomes in cancer drug delivery¹.

In terms of novel drug delivery system for anti-cancer research, Creative Biolabs is your best choice for your project. Because we are able to offer best customized products and services not only lipid-based anti-cancer drug delivery systems but also cancer-targeted PDC discovery.

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For Research Use Only. Not For Clinical Use