Lipids for LNP

Creative Biolabs has been working on the development of lipid-based drug delivery over the past decade, we proudly offer a full range of high-quality lipid products for lipid nanoparticle (LNP) technology. You can get all the lipids needed here in one-stop. The stability and effectiveness of the products are guaranteed to ensure that you get the best result for your research.

Lipid nanoparticles (LNPs) are novel core-shell nanostructured vesicles that carry nucleic acid material. A typical LNP mainly consists of four lipid components: a PEG lipid, ionizable (cationic) lipid, helper lipid, and cholesterol. The cationic lipids can absorb negatively charged nucleic acids through charge interaction. Ionizable lipids are designed to be protonated at low pH and become positively charged but remain neutral at physiological pH. This unique property of ionizable lipid can improve the biocompatibility of LNP and makes it a promising carrier for nucleic acid delivery. PEG lipid is another important component that helps reduce blood clearance and particle aggregation. Neutral helper lipids are generally saturated phospholipids, which can improve the phase transition temperature and stability of LNPs. Cholesterol has a strong membrane fusion ability are added to promote intracellular uptake and cytoplasmic entry.

As an experienced liposome supplier, Creative Biolabs has strict quality control on lipid products. LNPs made with our lipid products have been shown to have good delivery efficiency. Since the LNP formulation research is a complex task that needs to consider many important factors, we also offer customized LNP development services to provide you with the best-optimized solutions. For more information, please feel free to contact us.

For Research Use Only. Not For Clinical Use