Background of Liposome

Loading drugs in colloidal systems has become a promising tool for improving pharmacokinetics and ultimate clinical efficacy. These systems include a wide range of dispersions, such as submicron emulsion and colloidal particles, such as polymers and lipid nanoparticles, micelles and liposomes. They are also designed to protect drugs from degradation, ensure sustained and controlled release, and improve patient compliance by reducing the need for multi-dose treatment and reducing the side effects of drugs. Among them, liposome is an important branch of this colloidal particle system.

Entering Liposomes

Production costs and all other impacts must be taken into account when designing drug delivery formulations to improve drug efficacy. The cost of the preparation increases due to the use of expensive excipient materials and the costs associated with the expensive equipment required for manufacturing. There are also similar problems in liposome delivery system, such as the more commonly used cationic liposomes are highly toxic due to the high dose required for treatment; liposomes containing anticancer drugs lack of targeting in intravenous injection. These can lead to adverse reactions, such as hand-foot syndrome. In addition, the differences between batches in the production process, the need for extensive sterilization, reducing the encapsulation efficiency, particle size control, shelf life and residual trace organic solvents and other issues have also been of great concern.

Therefore, before interpreting and demonstrating the formulation development of liposome drug products, it is particularly important to understand the following properties:

Basic Knowledge of Liposomes

Liposomes are mainly composed of active substances and lipids but can contain functional lipids modified with, for example, polyethylene glycol (PEG) and/or ligands (targeted fractions). In addition, liposome preparations contain excipients, such as pH regulators and stabilizers, such as those found in common injections. Liposomes have unique properties and can be used in different scientific fields, including medicine and pharmacy, e.g. in oncology, ophthalmology, dermatology, genetics-as a carrier of drugs, vitamins, or minerals, in addition, they can also be used as a delivery system for dermocosmetology and cosmetology.

Fig.1 Basic knowledge of liposomes.

With the continuous improvement of technology, the existing liposome technology has shown excellent performance in the delivery of various active substances.

• Liposomes can help maintain long-term stable levels of active substances in the target area.
• Increase the bioavailability of transported substances.
• Effectively protect the transported active substance from the factors caused by degradation (such as low pH or the presence of free radicals).
• Optimized dosage.
• It can specifically deliver the substance to the desired location and improve the treatment effect.

Creative Biolabs provides contract services for the development of liposome pharmaceutical formulations for the pharmaceutical/biotechnology industry. We have strong and extensive expertise and years of experience in the field of drug delivery and lipid biophysics. For more details about our services, please directly contact us.

For Research Use Only. Not For Clinical Use